Derniers articles listés par NCBI PubMed sur les maladies inflammatoires du foie et des voies biliaires (en anglais)
Qu’est-ce que PubMed?
Pubmed est la Bibliothèque Nationale de Médecine américaine. Pubmed incorpore plus de 24 millions d’extraits de littérature biomédicale issus du service en ligne MEDLINE, de journaux et livres scientifiques. Les extraits incorporent parfois des liens vers les textes intégraux des articles ou vers les sites web des éditeurs. Ces documents sont des publications scientifiques relatant l’avancée de la recherche sur les maladies inflammatoires du foie et des voies biliaires. Ils sont relayés ici sur le site d’albi afin que les malades comme les professionnels de la santé se fassent une idée des thématiques d’études et des avancées de la recherche. Il faut bien comprendre que ces communications sont des résultats de recherches ponctuelles, qui doivent être validés par d’autres études, pour éventuellement déboucher sur des innovations thérapeutiques quelques années plus tard. Si vous êtes malade, il est évident que ces informations ne peuvent pas être prises en compte pour prendre l’initiative d’une quelconque modification de votre traitement, modification qui ne peut se faire que sous avis médical.
What is PubMed?
PubMed is the US National Library of Medicine. PubMed comprises more than 24 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
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New predictive factors of poor response to therapy in autoimmune hepatitis: role of mean platelet volume.New predictive factors of poor response to therapy in autoimmune hepatitis: role of mean platelet volume. Eur J Gastroenterol Hepatol. 2017 Oct 13;: Authors: Abdel-Razik A, Mousa N, Zakaria S, Elhelaly R, Elzehery R, Zalata K, Awad M, Eldeeb AA, Abdelsalam M Abstract BACKGROUND AND OBJECTIVES: The response to immunosuppressive therapy in autoimmune hepatitis (AIH)…
Involvement of the Nrf2/HO-1/CO axis and therapeutic intervention with the CO-Releasing Molecule CORM-A1, in a murine model of Autoimmune Hepatitis.Related Articles Involvement of the Nrf2/HO-1/CO axis and therapeutic intervention with the CO-Releasing Molecule CORM-A1, in a murine model of Autoimmune Hepatitis. J Cell Physiol. 2017 Oct 15;: Authors: Mangano K, Cavalli E, Mammana S, Basile MS, Caltabiano R, Pesce A, Puleo S, Atanasov AG, Magro G, Nicoletti F, Fagone P Abstract Concanavalin A (ConA)-induced…
Drug-Induced Autoimmune Hepatitis following Treatment with Zoledronic Acid.Related Articles Drug-Induced Autoimmune Hepatitis following Treatment with Zoledronic Acid. Case Rep Gastroenterol. 2017 May-Aug;11(2):440-445 Authors: Schneider JS, Montani M, Stickel F Abstract Adverse drug reactions are among the most frequent side effects of synthetic and complementary alternative drugs and represent the premier causes of license revocations and acute liver failure. Drug-induced liver injury can…
A Case of IgG4-related Lung Pseudotumor and Pleural Inflammation with Autoimmune Hepatitis.Related Articles A Case of IgG4-related Lung Pseudotumor and Pleural Inflammation with Autoimmune Hepatitis. Intern Med. 2017 Oct 16;: Authors: Nagashima K, Sano I, Kobayashi T, Eto K, Nagai K, Ninomiya R, Suzuki A, Oohata Y, Konishi K, Nakano T, Yamamoto F Abstract A 63-year-old man was admitted to our department following a secondary medical…
Nationwide survey for acute liver failure and late-onset hepatic failure in Japan.Related Articles Nationwide survey for acute liver failure and late-onset hepatic failure in Japan. J Gastroenterol. 2017 Oct 13;: Authors: Nakao M, Nakayama N, Uchida Y, Tomiya T, Ido A, Sakaida I, Yokosuka O, Takikawa Y, Inoue K, Genda T, Shimizu M, Terai S, Tsubouchi H, Takikawa H, Mochida S Abstract BACKGROUND: A nationwide survey…
A Randomized Trial of Obeticholic Acid Monotherapy in Patients with Primary Biliary Cholangitis.A Randomized Trial of Obeticholic Acid Monotherapy in Patients with Primary Biliary Cholangitis. Hepatology. 2017 Oct 10;: Authors: Kowdley KV, Luketic V, Chapman R, Hirschfield GM, Poupon R, Schramm C, Vincent C, Rust C, Parés A, Mason A, Shapiro D, Adorini L, Sciacca C, Beecher-Jones T, Böhm O, Pencek R, Jones D, Obeticholic Acid PBC…
Hepatic T Cell Tolerance Induction in An Inflammatory Environment.Hepatic T Cell Tolerance Induction in An Inflammatory Environment. Dig Dis. 2017 Oct 12;: Authors: Dywicki J, Noyan F, Misslitz AC, Hapke M, Galla M, Schlue J, Liblau RS, Taubert R, Manns MP, Jaeckel E, Hardtke-Wolenski M Abstract For the development of autoimmune hepatitis (AIH), genetic predisposition and environmental triggers are of major importance. Although…
The Best Choice for Second-Line Treatment in Standard Treatment-Refractory Children with Autoimmune Hepatitis.The Best Choice for Second-Line Treatment in Standard Treatment-Refractory Children with Autoimmune Hepatitis. J Pediatr Gastroenterol Nutr. 2017 Oct 10;: Authors: Nastasio S, Sciveres M, Maggiore G PMID: 29019854 [PubMed - as supplied by publisher]
Clinical characteristics of antimitochondrial antibody-positive patients at a safety net health care system in Arizona.Clinical characteristics of antimitochondrial antibody-positive patients at a safety net health care system in Arizona. BMJ Open Gastroenterol. 2017;4(1):e000158 Authors: Tan S, Ayutyanont N, Bhattarai B, Movahedi Z, Jayaram L, Gish R, Nadir A Abstract BACKGROUND AND AIMS: To assess whether aspartate aminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphatase (AP) levels can predict the…
IFN-γ-STAT1-iNOS Induces Myeloid Progenitors to Acquire Immunosuppressive Activity.IFN-γ-STAT1-iNOS Induces Myeloid Progenitors to Acquire Immunosuppressive Activity. Front Immunol. 2017;8:1192 Authors: Yang SH, Li L, Xie YQ, Yao Y, Gao CY, Liao LH, Ma HD, Gershwin ME, Lian ZX Abstract Autoimmune diseases often induce dysregulated hematopoiesis with altered number and function of hematopoietic stem and progenitor cells (HSPCs). However, there are limited studies on…
Prognostic scores and non-invasive markers in primary sclerosing cholangitis: good for patients or for papers?Prognostic scores and non-invasive markers in primary sclerosing cholangitis: good for patients or for papers? Lancet Gastroenterol Hepatol. 2017 Nov;2(11):774-776 Authors: Thorburn D PMID: 29017709 [PubMed - in process]
Effects of Bezafibrate on Outcome and Pruritus in Primary Biliary Cholangitis With Suboptimal Ursodeoxycholic Acid Response.Effects of Bezafibrate on Outcome and Pruritus in Primary Biliary Cholangitis With Suboptimal Ursodeoxycholic Acid Response. Am J Gastroenterol. 2017 Oct 10;: Authors: Reig A, Sesé P, Parés A Abstract OBJECTIVES: Adding fibrates improves liver biochemistries in patients with primary biliary cholangitis (PBC) and suboptimal response to ursodeoxycholic acid (UDCA). As there are no consistent…
From pathogenesis to novel therapies in the treatment of primary biliary cholangitis.From pathogenesis to novel therapies in the treatment of primary biliary cholangitis. Expert Rev Clin Immunol. 2017 Oct 10;: Authors: Ronca V, Carbone M, Bernuzzi F, Malinverno F, Mousa HS, Gershwin ME, Invernizzi P Abstract INTRODUCTION: Primary biliary cholangitis (PBC) is an immune-mediated liver disease characterized by chronic inflammation of the intrahepatic bile ducts, causing…
HMG CoA reductase inhibitor associated myositis and autoimmune hepatitis.HMG CoA reductase inhibitor associated myositis and autoimmune hepatitis. Intern Med J. 2017 Oct;47(10):1213-1215 Authors: Palamuthusingam D, Mantha M, Dheda S PMID: 28994254 [PubMed - in process]
Skin Manifestations Associated with Autoimmune Liver Diseases: a Systematic Review.Skin Manifestations Associated with Autoimmune Liver Diseases: a Systematic Review. Clin Rev Allergy Immunol. 2017 Oct 09;: Authors: Terziroli Beretta-Piccoli B, Invernizzi P, Gershwin ME, Mainetti C Abstract Autoimmune liver diseases, which include mainly autoimmune hepatitis, primary biliary cholangitis, primary sclerosing cholangitis, and the variant syndromes, are often associated with extrahepatic autoimmune diseases. However, the…
Twenty-year Comparative Analysis of Patients With Autoimmune Liver Diseases on Transplant Waitlists.Twenty-year Comparative Analysis of Patients With Autoimmune Liver Diseases on Transplant Waitlists. Clin Gastroenterol Hepatol. 2017 Oct 06;: Authors: Webb GJ, Rana A, Hodson J, Akhtar MZ, Ferguson JW, Neuberger JM, Vierling JM, Hirschfield GM Abstract BACKGROUND & AIMS: The rarity of autoimmune liver disease poses challenges to epidemiology studies. However, waitlists for liver transplantation…
Diabetes mellitus y atrofia óptica: estudio del síndrome de Wolfram.Diabetes mellitus y atrofia óptica: estudio del síndrome de Wolfram. Rev Invest Clin. 2017;153(4):468-474 Authors: Rivas-Gómez B, Reza-Albarrán AA Abstract Antecedentes: El síndrome de Wolfram (SW), también conocido por el acrónimo DIDMOAD, es una enfermedad hereditaria rara y progresiva, de transmisión autosómica recesiva, cuyos criterios diagnósticos mínimos son diabetes mellitus y atrofia óptica antes de…
Optimizing the detection of biliary dysplasia in primary sclerosing cholangitis before liver transplantation.Optimizing the detection of biliary dysplasia in primary sclerosing cholangitis before liver transplantation. Scand J Gastroenterol. 2017 Oct 09;:1-8 Authors: Majeed A, Castedal M, Arnelo U, Söderdahl G, Bergquist A, Said K Abstract BACKGROUND: Patients with primary sclerosing cholangitis (PSC) have increased risk of cholangiocarcinoma (CCA). We evaluated pre-transplant work-up in PSC patients, to search…
Clinical impact of intrapulmonary vascular dilatation in liver transplant candidates.Clinical impact of intrapulmonary vascular dilatation in liver transplant candidates. Chest. 2017 Oct 05;: Authors: DuBrock HM, Krowka MJ, Forde KA, Krok K, Patel M, Sharkoski T, Sprys M, Lin G, Oh JK, Mottram CD, Scanlon PD, Fallon MB, Kawut SM Abstract BACKGROUND: Intrapulmonary vascular dilatations (IPVD) are frequently detected in patients with liver disease…
Primary Sclerosing Cholangitis: What the Gastroenterologist and Hepatologist Needs to Know.Primary Sclerosing Cholangitis: What the Gastroenterologist and Hepatologist Needs to Know. Clin Liver Dis. 2017 Nov;21(4):725-737 Authors: Gossard AA, Gores GJ Abstract Primary sclerosing cholangitis (PSC) is a chronic, idiopathic biliary tract disease characterized by segmental strictures. The disease is progressive with no proven treatments and may eventually lead to cirrhosis and end-stage liver disease.…
An Update on the Treatment and Follow-up of Patients with Primary Biliary Cholangitis.An Update on the Treatment and Follow-up of Patients with Primary Biliary Cholangitis. Clin Liver Dis. 2017 Nov;21(4):709-723 Authors: Burman BE, Jhaveri MA, Kowdley KV Abstract Primary biliary cholangitis (PBC) is an autoimmune liver disease characterized by chronic granulomatous lymphocytic cholangitis of the small bile ducts. PBC was a leading indication for liver transplant in…
The Liver in Oncology.The Liver in Oncology. Clin Liver Dis. 2017 Nov;21(4):697-707 Authors: Dhanasekaran R, Kwo PY Abstract Gastroenterologists and hepatologists will encounter oncology patients who develop abnormal liver tests, patients with hepatic malignancies, and patients with acute and chronic liver disease who require chemotherapy or immediate evaluation. Chemotherapy can cause liver injury owing to toxic effects or…
Detection of anti-mitochondrial antibodies by immunoprecipitation in patients with systemic sclerosis.Detection of anti-mitochondrial antibodies by immunoprecipitation in patients with systemic sclerosis. J Immunol Methods. 2017 Oct 03;: Authors: Ceribelli A, Isailovic N, De Santis M, Generali E, Satoh M, Selmi C Abstract OBJECTIVE: To describe a new immunoprecipitation pattern identified in Italian patients affected by systemic sclerosis (SSc), corresponding to the pyruvate dehydrogenase antigen complex…
Long-term Risk of Cancer Following Ileal Pouch-anal Anastomosis for Ulcerative Colitis.Long-term Risk of Cancer Following Ileal Pouch-anal Anastomosis for Ulcerative Colitis. J Crohns Colitis. 2017 Aug 03;: Authors: Mark-Christensen A, Erichsen R, Brandsborg S, Rosenberg J, Qvist N, Thorlacius-Ussing O, Hillingsø J, Pachler JH, Christiansen EG, Laurberg S Abstract Background: The overall risk of cancer following ileal pouch-anal anastomosis [IPAA] is unknown, and pouch cancer…
Association of STAT4 and PTPN22 polymorphisms and their interactions with type-1 autoimmune hepatitis susceptibility in Chinese Han children.Related Articles Association of STAT4 and PTPN22 polymorphisms and their interactions with type-1 autoimmune hepatitis susceptibility in Chinese Han children. Oncotarget. 2017 Sep 22;8(37):60933-60940 Authors: Li X, Chen H, Cai Y, Zhang P, Chen Z Abstract AIMS: To investigate the impact of signal transducer and activator of transcription 4 (STAT4) and the protein tyrosine phosphatase…
PRIMARY SCLEROSING CHOLANGITIS IN CHILDREN AND ADOLESCENTS.PRIMARY SCLEROSING CHOLANGITIS IN CHILDREN AND ADOLESCENTS. Arq Gastroenterol. 2017 Oct 02;:0 Authors: Fagundes EDT, Ferreira AR, Hosken CC, Queiroz TCN Abstract BACKGROUND: Primary sclerosing cholangitis is a rare disease, but its prevalence has been underestimated in children and adolescents due to broad variation in clinical presentation as well as diagnostic challenges in this life…
The Role of Diagnosis and Treatment of Underlying Liver Disease for the Prognosis of Primary Liver Cancer.The Role of Diagnosis and Treatment of Underlying Liver Disease for the Prognosis of Primary Liver Cancer. Cancer Control. 2017 Jul-Sep;24(3):1073274817729240 Authors: Shiani A, Narayanan S, Pena L, Friedman M Abstract Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related deaths worldwide. Underlying chronic liver disease has been associated with an increased risk of…
Autoimmune Hepatitis: Diagnostic Dilemma When It Is Disguised as Iron Overload Syndrome.Autoimmune Hepatitis: Diagnostic Dilemma When It Is Disguised as Iron Overload Syndrome. J Clin Exp Hepatol. 2017 Sep;7(3):269-273 Authors: Acharya GK, Liao HI, Frunza-Stefan S, Patel R, Khaing M Abstract Elevated serum ferritin level is a common finding in iron overload syndrome, autoimmune and viral hepatitis, alcoholic and nonalcoholic fatty liver diseases. High transferrin saturation…
Characterization of Cerebral Edema in Acute-on-Chronic Liver Failure.Characterization of Cerebral Edema in Acute-on-Chronic Liver Failure. J Clin Exp Hepatol. 2017 Sep;7(3):190-197 Authors: Gupta T, Dhiman RK, Ahuja CK, Agrawal S, Chopra M, Kalra N, Duseja A, Taneja S, Khandelwal N, Chawla Y Abstract BACKGROUND AND AIMS: The nature of cerebral edema in acute-on-chronic liver failure (ACLF) is not well studied. We aimed…
Primary Sclerosing Cholangitis is Protective Against Non-alcoholic Fatty Liver Disease in Inflammatory Bowel Disease.Primary Sclerosing Cholangitis is Protective Against Non-alcoholic Fatty Liver Disease in Inflammatory Bowel Disease. Hum Pathol. 2017 Sep 29;: Authors: Bosch DE, Yeh MM Abstract Non-alcoholic fatty liver disease (NAFLD) occurs with higher prevalence in patients with inflammatory bowel disease (IBD) relative to the general population, and susceptibility is related to the metabolic syndrome, as…
Suspicious brush cytology is an indication for liver transplantation evaluation in primary sclerosing cholangitis.Suspicious brush cytology is an indication for liver transplantation evaluation in primary sclerosing cholangitis. World J Gastroenterol. 2017 Sep 07;23(33):6147-6154 Authors: Boyd S, Vannas M, Jokelainen K, Isoniemi H, Mäkisalo H, Färkkilä MA, Arola J Abstract AIM: To investigate markers for high-grade dysplasia for the optimal timing of liver transplantation in patients with primary sclerosing…
Patients with inflammatory bowel disease have increased risk of autoimmune and inflammatory diseases.Patients with inflammatory bowel disease have increased risk of autoimmune and inflammatory diseases. World J Gastroenterol. 2017 Sep 07;23(33):6137-6146 Authors: Halling ML, Kjeldsen J, Knudsen T, Nielsen J, Hansen LK Abstract AIM: To investigate whether immune mediated diseases (IMD) are more frequent in patients with inflammatory bowel disease (IBD). METHODS: In this population based registry…
Autoimmune hepatitis: Standard treatment and systematic review of alternative treatments.Autoimmune hepatitis: Standard treatment and systematic review of alternative treatments. World J Gastroenterol. 2017 Sep 07;23(33):6030-6048 Authors: Terziroli Beretta-Piccoli B, Mieli-Vergani G, Vergani D Abstract Autoimmune hepatitis is a rare chronic inflammatory liver disease, affecting all ages, characterised by elevated transaminase and immunoglobulin G levels, positive autoantibodies, interface hepatitis at liver histology and good response…
Marked decrease in urgent listing for liver transplantation over time: evolution of characteristics and outcomes of Status-1 liver transplantation.Marked decrease in urgent listing for liver transplantation over time: evolution of characteristics and outcomes of Status-1 liver transplantation. Transplantation. 2017 Sep 29;: Authors: Wong LL, Truong HP, Seto T, Lacar L, Naugler WE Abstract BACKGROUND: Approximately 5% of liver transplants annually are performed urgently with "status-1" designation. This study aims to determine if the…
Heterogeneity of Outcomes Following Liver Transplantation for Primary Sclerosing Cholangitis: Age Matters.Heterogeneity of Outcomes Following Liver Transplantation for Primary Sclerosing Cholangitis: Age Matters. Dig Dis Sci. 2017 Sep 30;: Authors: Martin P, Lindor KD PMID: 28965148 [PubMed - as supplied by publisher]
Antihistone Autoantibodies in Dobermans With Hepatitis.Antihistone Autoantibodies in Dobermans With Hepatitis. J Vet Intern Med. 2017 Sep 30;: Authors: Dyggve H, Meri S, Spillmann T, Jarva H, Speeti M Abstract BACKGROUND: Immune system involvement is suggested as an underlying cause for Doberman hepatitis (DH) based on female predisposition, lymphocyte infiltration, abnormal hepatocyte expression of major histocompatibility complex class II antigens,…
Role of the bicarbonate-responsive soluble adenylyl cyclase in cholangiocyte apoptosis in primary biliary cholangitis; a new hypothesis.Role of the bicarbonate-responsive soluble adenylyl cyclase in cholangiocyte apoptosis in primary biliary cholangitis; a new hypothesis. Biochim Biophys Acta. 2017 Sep 26;: Authors: Chang JC, Go S, Verhoeven AJ, Beuers U, Oude Elferink RPJ Abstract Primary biliary cholangitis (PBC) is a chronic fibrosing cholangiopathy characterized by an autoimmune stereotype and defective biliary bicarbonate secretion…
Safety and Efficacy of Biologic Agents for the Management of Inflammatory Bowel Disease After Liver Transplantation.Safety and Efficacy of Biologic Agents for the Management of Inflammatory Bowel Disease After Liver Transplantation. Pharmacotherapy. 2017 Sep 27;: Authors: Shaikh SA, Stuckey L, Tischer S Abstract Primary sclerosing cholangitis (PSC) frequently progresses to end-stage liver disease and cirrhosis, requiring liver transplantation. Approximately 70% of patients with PSC have concomitant inflammatory bowel disease (IBD)…
Association between primary biliary cholangitis and osteoporosis: meta-analysis.Related Articles Association between primary biliary cholangitis and osteoporosis: meta-analysis. Clin Rheumatol. 2017 Sep 26;: Authors: Fan J, Wang Q, Sun L Abstract The relationship between primary biliary cholangitis (PBC, previously termed primary biliary cirrhosis) and risks of osteoporosis remains controversial. This meta-analysis was designed to comprehensively analyze the association between PBC and osteoporosis. We…
Anti-TNFα Treatment in Children and Adolescents With Combined Inflammatory Bowel Disease and Autoimmune Liver Disease.Related Articles Anti-TNFα Treatment in Children and Adolescents With Combined Inflammatory Bowel Disease and Autoimmune Liver Disease. J Pediatr Gastroenterol Nutr. 2017 Sep 26;: Authors: Nedelkopoulou N, Vadamalayan B, Vergani D, Mieli-Vergani G Abstract OBJECTIVES: Inflammatory bowel disease (IBD) and autoimmune liver disease (AILD) are closely associated, the former often dictating progression of the latter.…
Cholangiocarcinoma and its mimickers in primary sclerosing cholangitis.Related Articles Cholangiocarcinoma and its mimickers in primary sclerosing cholangitis. Abdom Radiol (NY). 2017 Sep 26;: Authors: Lee JJ, Schindera ST, Jang HJ, Fung S, Kim TK Abstract Cholangiocarcinoma (CCA) is the most common malignancy in primary sclerosing cholangitis (PSC). Approximately half of CCA are diagnosed within two years of initial diagnosis and often have…
Efficacy of oral vancomycin in recurrent primary sclerosing cholangitis following liver transplantation.Related Articles Efficacy of oral vancomycin in recurrent primary sclerosing cholangitis following liver transplantation. BMJ Case Rep. 2017 Sep 25;2017: Authors: Hey P, Lokan J, Johnson P, Gow P Abstract Primary sclerosing cholangitis (PSC) is a liver disease that leads to progressive destruction and stricturing of the biliary tree. Unfortunately, apart from orthotopic liver transplantation…
Increased cholestatic enzymes in two patients with long-term history of ulcerative colitis: consider primary biliary cholangitis not always primary sclerosing cholangitis.Related Articles Increased cholestatic enzymes in two patients with long-term history of ulcerative colitis: consider primary biliary cholangitis not always primary sclerosing cholangitis. BMJ Case Rep. 2017 Sep 25;2017: Authors: Polychronopoulou E, Lygoura V, Gatselis NK, Dalekos GN Abstract Several hepatobiliary disorders have been reported in ulcerative colitis (UC) patients with primary sclerosing cholangitis (PSC)…
Pathological features of primary sclerosing cholangitis identified by bile proteomic analysis.Pathological features of primary sclerosing cholangitis identified by bile proteomic analysis. Biochim Biophys Acta. 2017 Sep 21;: Authors: Rupp C, Bode KA, Leopold Y, Sauer P, Gotthardt DN Abstract Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease of unknown origin. Previous bile proteomic analyses in patients with PSC have revealed changes in disease…
Assessment of the Visual Analogue Score in the Evaluation of the Pruritus of Cholestasis.Related Articles Assessment of the Visual Analogue Score in the Evaluation of the Pruritus of Cholestasis. J Clin Transl Hepatol. 2017 Sep 28;5(3):203-207 Authors: Bergasa NV, Jones EA Abstract Background and Aims: A visual analogue score (VAS), based on application of a visual analogue scale, has been widely used to assess pruritus in clinical studies…Dysregulation of Circulating Tfr/Tfh Ratio in Primary biliary cholangitis.Dysregulation of Circulating Tfr/Tfh Ratio in Primary biliary cholangitis. Scand J Immunol. 2017 Sep 23;: Authors: Zheng J, Wang T, Zhang L, Cui L Abstract Follicular helper T (Tfh) cells and follicular regulatory T (Tfr) cells are critical for the development and maintenance of germinal center (GC) and humoral immune responses. Accumulating evidence has demonstrated…
Complete resolution of extensive xanthomas associated with primary sclerosing cholangitis following liver transplantation.Complete resolution of extensive xanthomas associated with primary sclerosing cholangitis following liver transplantation. Clin Exp Dermatol. 2017 Sep 22;: Authors: Ghadiri SJ, Gunputh P, Poyner EFM, Carmichael AJ PMID: 28940652 [PubMed - as supplied by publisher]
Serum Wisteria Floribunda Agglutinin-Positive Mac-2 Binding Protein Could Not Always Predict Early Cirrhosis in Non-Viral Liver Diseases.Related Articles Serum Wisteria Floribunda Agglutinin-Positive Mac-2 Binding Protein Could Not Always Predict Early Cirrhosis in Non-Viral Liver Diseases. Diseases. 2016 Dec 14;4(4): Authors: Haga Y, Kanda T, Sasaki R, Nakamura M, Takahashi K, Wu S, Yasui S, Arai M, Nakamoto S, Yokosuka O Abstract BACKGROUND: Wisteria floribunda agglutinin-positive human Mac-2-binding protein (WFA(+)-M2BP) is a…
CHOP-induced loss of intestinal epithelial stemness contributes to bile duct ligation-induced cholestatic liver injury.Related Articles CHOP-induced loss of intestinal epithelial stemness contributes to bile duct ligation-induced cholestatic liver injury. Hepatology. 2017 Sep 19;: Authors: Liu R, Li X, Huang Z, Zhao D, Ganesh BS, Lai G, Pandak WM, Hylemon PB, Bajaj JS, Sanyal AJ, Zhou H Abstract Impaired intestinal barrier function promotes the progression of various liver diseases…
MiRNA-506 promotes primary biliary cholangitis-like features in cholangiocytes and immune activation.Related Articles MiRNA-506 promotes primary biliary cholangitis-like features in cholangiocytes and immune activation. Hepatology. 2017 Sep 18;: Authors: Erice O, Munoz-Garrido P, Vaquero J, Perugorria MJ, Fernandez-Barrena MG, Saez E, Santos-Laso A, Arbelaiz A, Jimenez-Agüero R, Fernandez-Irigoyen J, Santamaria E, Torrano V, Carracedo A, Ananthanarayanan M, Marzioni M, Prieto J, Beuers U, Oude Elferink RP,…
Genetic Risk Factors for Autoimmune Thyroid Disease might Affect the Susceptibility to and Modulate the Progression of Primary Biliary Cholangitis.Related Articles Genetic Risk Factors for Autoimmune Thyroid Disease might Affect the Susceptibility to and Modulate the Progression of Primary Biliary Cholangitis. J Gastrointestin Liver Dis. 2017 Sep;26(3):245-252 Authors: Kuś A, Arłukowicz-Grabowska M, Szymański K, Wunsch E, Milkiewicz M, Płoski R, Shums Z, Norman GL, Milkiewicz P, Bednarczuk T, Krawczyk M Abstract BACKGROUND AND AIMS:…
Complications, Symptoms, Quality of Life, and Pregnancy in Cholestatic Liver Disease.Related Articles Complications, Symptoms, Quality of Life, and Pregnancy in Cholestatic Liver Disease. Liver Int. 2017 Sep 18;: Authors: Zakharia K, Tabibian A, Lindor KD, Tabibian JH Abstract Cholestatic liver diseases (CLDs) encompass a variety of disorders of bile formation and/or flow which generally result in progressive hepatobiliary injury and ultimately end-stage liver disease. Many…
The interplay of type I and type II interferons in murine autoimmune cholangitis as a basis for sex-biased autoimmunity.Related Articles The interplay of type I and type II interferons in murine autoimmune cholangitis as a basis for sex-biased autoimmunity. Hepatology. 2017 Sep 16;: Authors: Bae HR, Hodge DL, Yang GX, Leung PSC, Chodisetti SB, Valencia JC, Sanford M, Fenimore JM, Rahman ZSM, Tsuneyama K, Norman GL, Gershwin ME, Young HA Abstract We have…
[Autoimmune hepatitis: Immunological diagnosis].Related Articles [Autoimmune hepatitis: Immunological diagnosis]. Presse Med. 2017 Sep 14;: Authors: Brahim I, Brahim I, Hazime R, Admou B Abstract Autoimmune hepatopathies (AIHT) including autoimmune hepatitis (AIH), primary biliary cirrhosis (PBC), primary sclerosing cholangitis (PSC) and autoimmune cholangitis (AIC), represent an impressive entities in clinical practice. Their pathogenesis is not perfectly elucidated. Several factors…
Primary Sjögren's syndrome: Extraglandular manifestations and hydroxychloroquine therapy.Related Articles Primary Sjögren's syndrome: Extraglandular manifestations and hydroxychloroquine therapy. Clin Rheumatol. 2017 Sep 14;: Authors: Demarchi J, Papasidero S, Medina MA, Klajn D, Chaparro Del Moral R, Rillo O, Martiré V, Crespo G, Secco A, Catalan Pellet A, Amitrano C, Crow C, Asnal C, Pucci P, Caeiro F, Benzanquen N, Pirola JP, Mayer M,…
A brief review on prognostic models of primary biliary cholangitis.Related Articles A brief review on prognostic models of primary biliary cholangitis. Hepatol Int. 2017 Sep 14;: Authors: Chen S, Duan W, You H, Jia J Abstract Primary biliary cholangitis (PBC), previously known as primary biliary cirrhosis, is an autoimmune liver disease characterized by progressive destruction of small intrahepatic bile ducts. If left untreated, PBC…
RAN Translation Regulated by Muscleblind Proteins in Myotonic Dystrophy Type 2.Related Articles RAN Translation Regulated by Muscleblind Proteins in Myotonic Dystrophy Type 2. Neuron. 2017 Sep 13;95(6):1292-1305.e5 Authors: Zu T, Cleary JD, Liu Y, Bañez-Coronel M, Bubenik JL, Ayhan F, Ashizawa T, Xia G, Clark HB, Yachnis AT, Swanson MS, Ranum LPW Abstract Several microsatellite-expansion diseases are characterized by the accumulation of RNA foci and…
Autoimmune hepatitis and HIV infection: two case reports and review of the literature.Related Articles Autoimmune hepatitis and HIV infection: two case reports and review of the literature. AIDS. 2017 Sep 24;31(15):2172-2175 Authors: Zoboli F, Ripamonti D, Benatti SV, Comi L, Rizzi M PMID: 28906281 [PubMed - in process]
IgG4-Related Cholangiopathy and Its Mimickers: A Case Report and Review Highlighting the Importance of Early Diagnosis.Related Articles IgG4-Related Cholangiopathy and Its Mimickers: A Case Report and Review Highlighting the Importance of Early Diagnosis. Int J Surg Pathol. 2017 Sep 01;:1066896917730902 Authors: Geary K, Yazici C, Seibold A, Guzman G Abstract Immunoglobulin (Ig) G4 (IgG4)-related disease is a recently described clinical entity that can involve multiple organs. It is an autoimmune…
Review article: next-generation transformative advances in the pathogenesis and management of autoimmune hepatitis.Review article: next-generation transformative advances in the pathogenesis and management of autoimmune hepatitis. Aliment Pharmacol Ther. 2017 Sep 13;: Authors: Czaja AJ Abstract BACKGROUND: Advances in autoimmune hepatitis that transform current concepts of pathogenesis and management can be anticipated as products of ongoing investigations driven by unmet clinical needs and an evolving biotechnology. AIM: To…
"Autoimmune(-Like)" Drug and Herb Induced Liver Injury: New Insights into Molecular Pathogenesis."Autoimmune(-Like)" Drug and Herb Induced Liver Injury: New Insights into Molecular Pathogenesis. Int J Mol Sci. 2017 Sep 12;18(9): Authors: Sebode M, Schulz L, Lohse AW Abstract Idiosyncratic drug-induced liver injury (DILI) and hepatic injury due to herbal and dietary supplements (HDS) can adapt clinical characteristics of autoimmune hepatitis (AIH), such as the appearance of…
Principal contribution of HLA-DQ alleles, DQB1*06:04 and DQB1*03:01, to disease resistance against primary biliary cholangitis in a Japanese population.Related Articles Principal contribution of HLA-DQ alleles, DQB1*06:04 and DQB1*03:01, to disease resistance against primary biliary cholangitis in a Japanese population. Sci Rep. 2017 Sep 11;7(1):11093 Authors: Yasunami M, Nakamura H, Tokunaga K, Kawashima M, Nishida N, Hitomi Y, Nakamura M Abstract Identification of the primary allele(s) in HLA class II associated diseases remains challenging…
Methotrexate therapy for Autoimmune Hepatitis: Response to letter to the editor by Efe et al.Related Articles Methotrexate therapy for Autoimmune Hepatitis: Response to letter to the editor by Efe et al. Clin Gastroenterol Hepatol. 2017 Sep 08;: Authors: Haridy J, Nicoll A, Sood S PMID: 28893680 [PubMed - as supplied by publisher]
Inflammatory myopathy associated with antimitochondrial antibodies: A distinct phenotype with cardiac involvement.Related Articles Inflammatory myopathy associated with antimitochondrial antibodies: A distinct phenotype with cardiac involvement. Semin Arthritis Rheum. 2017 Jun 13;: Authors: Albayda J, Khan A, Casciola-Rosen L, Corse AM, Paik JJ, Christopher-Stine L Abstract OBJECTIVE: In the context of clinical evaluations performed on our prospective myositis cohort, we noted a striking association of severe cardiac…
Autoimmune Hepatitis - Primary Biliary Cirrhosis Overlap Syndrome.Related Articles Autoimmune Hepatitis - Primary Biliary Cirrhosis Overlap Syndrome. J Clin Diagn Res. 2017 Jul;11(7):OD07-OD09 Authors: Bairy I, Berwal A, Seshadri S Abstract Autoimmune Hepatitis (AIH) and Primary Biliary Cirrhosis (PBC) are important immune mediated liver diseases. They are usually differentiated based on clinical, biochemical, serological and histological parameters. The presence of autoantibodies, clinical…
Hepatic inflammation caused by dysregulated bile acid synthesis is reversible by butyrate supplementation.Hepatic inflammation caused by dysregulated bile acid synthesis is reversible by butyrate supplementation. J Pathol. 2017 Sep 11;: Authors: Sheng L, Jena PK, Hu Y, Liu HX, Nagar N, Kalanetra KM, French SW, French SW, Mills DA, Wan YY Abstract Dysregulated bile acid (BA) synthesis or reduced farnesoid x receptor (FXR) levels are found in…
Development and characterization of cholangioids from normal and diseased human cholangiocytes as an in vitro model to study primary sclerosing cholangitis.Development and characterization of cholangioids from normal and diseased human cholangiocytes as an in vitro model to study primary sclerosing cholangitis. Lab Invest. 2017 Sep 11;: Authors: Loarca L, De Assuncao TM, Jalan-Sakrikar N, Bronk S, Krishnan A, Huang B, Morton L, Trussoni C, Bonilla LM, Krueger E, O'Hara S, Splinter P, Shi G, Pisarello…
Liver Failure as the Presentation of Ornithine Transcarbamylase Deficiency in a 13-Month-Old Female.Related Articles Liver Failure as the Presentation of Ornithine Transcarbamylase Deficiency in a 13-Month-Old Female. JIMD Rep. 2017 Sep 09;: Authors: Rajabi F, Rodan LH, Jonas MM, Soul JS, Ullrich NJ, Wessel A, Waisbren SE, Tan WH, Berry GT Abstract Ornithine transcarbamylase deficiency (OTCD) is an X-linked urea cycle disorder with variable expressivity in heterozygous…
MicroRNA-223 and microRNA-21 in peripheral blood B cells associated with progression of primary biliary cholangitis patients.MicroRNA-223 and microRNA-21 in peripheral blood B cells associated with progression of primary biliary cholangitis patients. PLoS One. 2017;12(9):e0184292 Authors: Wang X, Wen X, Zhou J, Qi Y, Wu R, Wang Y, Kui Y, Hua R, Jin Q Abstract Recently, there is ample evidence suggesting the important role of microRNAs (miRNAs) in autoimmune diseases via…
Autoimmune hepatitis - update on clinical management in 2017.Autoimmune hepatitis - update on clinical management in 2017. Clin Res Hepatol Gastroenterol. 2017 Sep 04;: Authors: Liwinski T, Schramm C Abstract Autoimmune hepatitis (AIH) is a progressive immune mediated liver disease of unknown origin. Key diagnostic features include hypergammaglobulinemia/elevated serum-IgG, characteristic circulating autoantibodies, periportal hepatitis with interface activity on liver biopsy and the exclusion of hepatotropic…
Drug-induced bile duct injury.Drug-induced bile duct injury. Biochim Biophys Acta. 2017 Sep 04;: Authors: Visentin M, Lenggenhager D, Gai Z, Kullak-Ublick GA Abstract Drug-induced liver injury includes a spectrum of pathologies, some related to the mode of injury, some to the cell type primarily damaged. Among these, drug-induced bile duct injury is characterized by the destruction of the…
Association of autoimmune hepatitis type 1 in a child with Evans syndrome.Related Articles Association of autoimmune hepatitis type 1 in a child with Evans syndrome. World J Hepatol. 2017 Aug 18;9(23):1008-1012 Authors: Jarasvaraparn C, Imran H, Siddiqui A, Wilson F, Gremse DA Abstract Autoimmune hepatitis (AIH) is a progressive liver disease that is often associated with extrahepatic autoimmune disorders. Evans syndrome (ES) is a rare autoimmune…
Prevalence of pruritus in patients with chronic liver disease: a multicenter study.Prevalence of pruritus in patients with chronic liver disease: a multicenter study. Hepatol Res. 2017 Sep 06;: Authors: Oeda S, Takahashi H, Yoshida H, Ogawa Y, Imajo K, Yoneda M, Koshiyama Y, Ono M, Hyogo H, Kawaguchi T, Fujii H, Nishino K, Sumida Y, Tanaka S, Kawanaka M, Torimura T, Saibara T, Kawaguchi A, Nakajima…
Treatment Response and Outcome with Two Different Prednisolone Regimens in Autoimmune Hepatitis.Related Articles Treatment Response and Outcome with Two Different Prednisolone Regimens in Autoimmune Hepatitis. Dig Dis Sci. 2017 Sep 04;: Authors: Purnak T, Efe C, Kav T, Wahlin S, Ozaslan E Abstract BACKGROUND: Beyond available guidelines, therapy of autoimmune hepatitis (AIH) shows wide variation among physicians. We compared two regimens for treatment naive AIH: one…
Management of Autoimmune Hepatitis in Pregnant Women.Related Articles Management of Autoimmune Hepatitis in Pregnant Women. Gastroenterol Hepatol (N Y). 2017 Aug;13(8):504-506 Authors: Peters MG PMID: 28867984 [PubMed]
Histopathological Challenges in Suspected Drug-Induced Liver Injury.Histopathological Challenges in Suspected Drug-Induced Liver Injury. Liver Int. 2017 Sep 02;: Authors: Kleiner DE Abstract When a patient with suspected drug-induced liver injury (DILI) undergoes liver biopsy, the pathologist is confronted with two major challenges. The first and most important is to establish the pattern(s) of injury which are present. Patterns of injury represent…
Gene-disease associations identify a connectome with shared molecular pathways in human cholangiopathies.Gene-disease associations identify a connectome with shared molecular pathways in human cholangiopathies. Hepatology. 2017 Sep 02;: Authors: Luo Z, Jegga AG, Bezerra JA Abstract Cholangiopathies are a diverse group of progressive diseases whose primary cell targets are cholangiocytes. To identify shared pathogenesis and molecular connectivity among the three main human cholangiopathies (biliary atresia [BA], primary…
Liver involvement in children with collagen vascular diseases.Related Articles Liver involvement in children with collagen vascular diseases. Clin Exp Hepatol. 2015 Nov;1(3):117-119 Authors: Pawłowska J, Naorniakowska M, Liber A Abstract Liver injury such as hepatomegaly, splenomegaly and various degrees of biochemical abnormalities are quite common in children with collagen vascular diseases. They may be primary or secondary, particularly due to drug therapy…
New developments in the treatment of primary biliary cholangitis - role of obeticholic acid.Related Articles New developments in the treatment of primary biliary cholangitis - role of obeticholic acid. Ther Clin Risk Manag. 2017;13:1053-1060 Authors: Jhaveri MA, Kowdley KV Abstract Primary biliary cholangitis (PBC) is a chronic autoimmune cholestatic liver disease that predominantly affects women in early to middle age. It is typically associated with autoantibodies to mitochondrial…
Epidemiology and Natural History of Primary Biliary Cholangitis in the Chinese: A Territory-Based Study in Hong Kong between 2000 and 2015.Epidemiology and Natural History of Primary Biliary Cholangitis in the Chinese: A Territory-Based Study in Hong Kong between 2000 and 2015. Clin Transl Gastroenterol. 2017 Aug 31;8(8):e116 Authors: Cheung KS, Seto WK, Fung J, Lai CL, Yuen MF Abstract OBJECTIVES: Studies on the epidemiology of primary biliary cholangitis (PBC) in the Chinese population are lacking.…
Recreational Exposure during Algal Bloom in Carrasco Beach, Uruguay: A Liver Failure Case Report.Recreational Exposure during Algal Bloom in Carrasco Beach, Uruguay: A Liver Failure Case Report. Toxins (Basel). 2017 Aug 31;9(9): Authors: Vidal F, Sedan D, D'Agostino D, Cavalieri ML, Mullen E, Parot Varela MM, Flores C, Caixach J, Andrinolo D Abstract In January 2015, a 20-month-old child and her family took part in recreational activities at…
Acute-on-chronic hepatitis. A case report of autoimmune hepatitis/primary sclerosing cholangitis/ulcerative colitis overlap syndrome in a 15-year-old patient.Acute-on-chronic hepatitis. A case report of autoimmune hepatitis/primary sclerosing cholangitis/ulcerative colitis overlap syndrome in a 15-year-old patient. Clin Exp Hepatol. 2017 Mar;3(1):28-32 Authors: Nalepa A, Woźniak M, Cielecka-Kuszyk J, Stefanowicz M, Jankowska I, Dądalski M, Pawłowska J Abstract Acute-on-chronic liver failure (ACLF) is a disease in which a rapid deterioration of liver function occurs in…
The occurrence of autoantibodies in patients with chronic HCV infection, including patients dialyzed and after kidney transplantation.The occurrence of autoantibodies in patients with chronic HCV infection, including patients dialyzed and after kidney transplantation. Clin Exp Hepatol. 2016 Dec;2(4):161-166 Authors: Łapiński TW, Rogalska-Płońska M, Parfieniuk-Kowerda A, Świderska M, Flisiak R Abstract INTRODUCTION: There are reports suggesting that hepatitis C virus (HCV) may stimulate the autoimmune process. Studies have been undertaken to evaluate…
The Role of Proinflammatory Pathways in the Pathogenesis of Colitis-Associated Colorectal Cancer.Related Articles The Role of Proinflammatory Pathways in the Pathogenesis of Colitis-Associated Colorectal Cancer. Mediators Inflamm. 2017;2017:5126048 Authors: Luo C, Zhang H Abstract Patients with inflammatory bowel disease (IBD) are at an increased risk of developing colorectal cancer (CRC). The risk factors of CRC in IBD patients include long disease duration, extensive colitis, severe histological…
Does transient elastography correlate with liver fibrosis in patients with PSC? Laennec score-based analysis of explanted livers.Related Articles Does transient elastography correlate with liver fibrosis in patients with PSC? Laennec score-based analysis of explanted livers. Scand J Gastroenterol. 2017 Aug 29;:1-6 Authors: Krawczyk M, Ligocka J, Ligocki M, Raszeja-Wyszomirska J, Milkiewicz M, Szparecki G, Ilczuk T, Górnicka B, Zieniewicz K, Krawczyk M, Lammert F, Milkiewicz P Abstract BACKGROUND AND AIMS: Previous…
Nerve Infiltration by Benign Biliary Glands - A Diagnostic Dilemma.Nerve Infiltration by Benign Biliary Glands - A Diagnostic Dilemma. Histopathology. 2017 Aug 29;: Authors: Ryan C, Conlon N, Bennett MW, Heffron CCBB Abstract Perineural and intraneural infiltration is most often considered a diagnostic feature of malignancy but has been demonstrated in benign entities in a variety of organs. This brief report describes benign glands…
Endpoints in the design of clinical trials for primary sclerosing cholangitis.Related Articles Endpoints in the design of clinical trials for primary sclerosing cholangitis. Biochim Biophys Acta. 2017 Aug 25;: Authors: Ponsioen CY Abstract Primary sclerosing cholangitis is an enigmatic disease affecting the bile ducts, eventually leading to liver failure necessitating liver transplantation in many cases. There is currently no therapy that has proven to halt…
Bile acid receptors in the biliary tree: TGR5 in physiology and disease.Related Articles Bile acid receptors in the biliary tree: TGR5 in physiology and disease. Biochim Biophys Acta. 2017 Aug 24;: Authors: Deutschmann K, Reich M, Klindt C, Dröge C, Spomer L, Häussinger D, Keitel V Abstract Bile salts represent signalling molecules with a variety of endocrine functions. Bile salt effects are mediated by different receptor…
Optimising the clinical strategy for autoimmune liver diseases: Principles of value-based medicine.Related Articles Optimising the clinical strategy for autoimmune liver diseases: Principles of value-based medicine. Biochim Biophys Acta. 2017 Aug 24;: Authors: Carbone M, Cristoferi L, Cortesi PA, Rota M, Ciaccio A, Okolicsanyi S, Gemma M, Scalone L, Cesana G, Fabris L, Colledan M, Fagiuoli S, Ideo G, Belli LS, Munari LM, Mantovani L, Strazzabosco M…
How the biliary tree maintains immune tolerance?Related Articles How the biliary tree maintains immune tolerance? Biochim Biophys Acta. 2017 Aug 24;: Authors: Zhang H, Leung PSC, Eric Gershwin M, Ma X Abstract The liver is a vital organ with distinctive anatomy, histology and heterogeneous cell populations. These characteristics are of particular importance in maintaining immune homeostasis within the liver microenvironments, notably…
Cholangiocytes in the pathogenesis of primary sclerosing cholangitis and development of cholangiocarcinoma.Related Articles Cholangiocytes in the pathogenesis of primary sclerosing cholangitis and development of cholangiocarcinoma. Biochim Biophys Acta. 2017 Aug 24;: Authors: Chung BK, Karlsen TH, Folseraas T Abstract Primary sclerosing cholangitis (PSC) is an idiopathic cholangiopathy strongly associated with inflammatory bowel disease (IBD) and characterized by cholestasis, chronic immune infiltration and progressive fibrosis of the…
Methotrexate in the treatment of autoimmune hepatitis.Related Articles Methotrexate in the treatment of autoimmune hepatitis. Clin Gastroenterol Hepatol. 2017 Aug 24;: Authors: Efe C, Ozaslan E, Purnak T PMID: 28844782 [PubMed - as supplied by publisher]
Change in nomenclature for the immunologic synapse from Troxis Necrosis to trogocytosis.Change in nomenclature for the immunologic synapse from Troxis Necrosis to trogocytosis. Exp Mol Pathol. 2017 Aug 23;: Authors: French SW Abstract The immunologic synapse mechanism of liver necrosis was termed Troxis Necrosis meaning "nibbling". (Wang MX et al. and French SW. Exp Mol Pathol 2001, 71: 137-146). This mechanism of liver injury was first…
Pure white cell aplasia: report of first case associated with autoimmune hepatitis.Related Articles Pure white cell aplasia: report of first case associated with autoimmune hepatitis. Frontline Gastroenterol. 2014 Oct;5(4):287-290 Authors: Keast T, Weeraman D, Mayhead P, Grace R, Mathe S Abstract Pure white cell aplasia (PWCA) is a rare, immune-mediated condition that causes a profound inhibition of myelopoiesis. It has been seen in association with other…
Current concepts in the diagnosis and management of autoimmune hepatitis.Related Articles Current concepts in the diagnosis and management of autoimmune hepatitis. Frontline Gastroenterol. 2013 Jan;4(1):2-11 Authors: Kriese S, Heneghan MA Abstract Autoimmune hepatitis (AIH) is a progressive necroinflammatory liver disease associated with significant morbidity and mortality. Mainly affecting females, AIH has a varied clinical presentation from minor symptomatology to acute liver failure. The diagnosis…
Improving outpatient services: the Southampton IBD virtual clinic.Related Articles Improving outpatient services: the Southampton IBD virtual clinic. Frontline Gastroenterol. 2012 Apr;3(2):76-80 Authors: Hunter J, Claridge A, James S, Chan D, Stacey B, Stroud M, Patel P, Fine D, Cummings JRF Abstract The follow-up of inflammatory bowel disease (IBD) patients is challenging due to the relapsing remitting nature of the diseases, the wide…
Successful Treatment of Stricture of Duct-to-Duct Biliary Anastomosis After Living-Donor Liver Transplantation of the Left Lobe: A Case Report.Related Articles Successful Treatment of Stricture of Duct-to-Duct Biliary Anastomosis After Living-Donor Liver Transplantation of the Left Lobe: A Case Report. Transplant Proc. 2017 Sep;49(7):1644-1648 Authors: Nakaseko Y, Shiba H, Yamanouchi E, Takano Y, Sakamoto T, Imazu H, Ashida H, Yanaga K Abstract Biliary complications, such as stricture or obstruction, after living-donor liver transplantation (LDLT) remain major…
Risk of malignancies in autoimmune hepatitis type 1 patients with a long-term follow-up in Japan.Risk of malignancies in autoimmune hepatitis type 1 patients with a long-term follow-up in Japan. Hepatol Res. 2017 Aug 25;: Authors: Arinaga-Hino T, Ide T, Miyajima I, Ogata K, Kuwahara R, Amano K, Kawaguchi T, Nakamura T, Kawaguchi T, Koga H, Yonemoto K, Torimura T, Kurume Autoimmune Hepatitis Study Group Abstract BACKGROUNDS/AIMS: The risk of…
Hemoperitoneum Secondary to Spontaneous Rupture of a Retroperitoneal Varix.Related Articles Hemoperitoneum Secondary to Spontaneous Rupture of a Retroperitoneal Varix. Case Reports Hepatol. 2017;2017:1829676 Authors: Eichele DD Abstract Hemoperitoneum due to a ruptured retroperitoneal varix is an exceedingly rare condition and a poor prognostic sign with catastrophic and life-threatening complication of portal hypertension. We present a unique case of a 56-year-old female with cirrhosis…
Primary biliary cholangitis: new treatments for an old disease.Related Articles Primary biliary cholangitis: new treatments for an old disease. Frontline Gastroenterol. 2017 Jan;8(1):29-36 Authors: Trivedi HD, Lizaola B, Tapper EB, Bonder A Abstract Primary biliary cholangitis (PBC) is an immunological condition that causes a significant health disturbance and dramatically reduces the quality of life for those affected with the disease. It is a…
Autoimmune liver disease: evaluating overlapping and cross-over presentations-a case-based discussion.Related Articles Autoimmune liver disease: evaluating overlapping and cross-over presentations-a case-based discussion. Frontline Gastroenterol. 2016 Oct;7(4):240-245 Authors: Corrigan M, Hirschfield GM Abstract The three classic autoimmune liver diseases are recognised based on identifying varying clinical, laboratory, histological and radiological features that collectively classify patients. In the absence of defined aetiological factors, it is recognised that…
Gut barrier failure biomarkers are associated with poor disease outcome in patients with primary sclerosing cholangitis.Related Articles Gut barrier failure biomarkers are associated with poor disease outcome in patients with primary sclerosing cholangitis. World J Gastroenterol. 2017 Aug 07;23(29):5412-5421 Authors: Tornai T, Palyu E, Vitalis Z, Tornai I, Tornai D, Antal-Szalmas P, Norman GL, Shums Z, Veres G, Dezsofi A, Par G, Par A, Orosz P, Szalay F, Lakatos PL,…
Investigational Drugs in Phase II Clinical Trials for Primary Biliary Cholangitis.Investigational Drugs in Phase II Clinical Trials for Primary Biliary Cholangitis. Expert Opin Investig Drugs. 2017 Aug 24;: Authors: Silveira MG, Lindor KD Abstract INTRODUCTION: Primary biliary cholangitis (PBC) is a chronic cholestatic liver disease that may lead to biliary fibrosis, and eventually cirrhosis. The primary treatment for PBC is ursodeoxycholic acid (UDCA), which has…
Histological improvement of liver fibrosis in well-treated patients with autoimmune hepatitis: A cohort study.Histological improvement of liver fibrosis in well-treated patients with autoimmune hepatitis: A cohort study. Medicine (Baltimore). 2017 Aug;96(34):e7708 Authors: Borssén ÅD, Palmqvist R, Kechagias S, Marschall HU, Bergquist A, Rorsman F, Weiland O, Verbaan H, Nyhlin N, Nilsson E, Werner M Abstract Autoimmune hepatitis (AIH) is a chronic autoimmune liver disease that if left untreated…
Clonal Characteristics of Paired Infiltrating and Circulating B Lymphocyte Repertoire in Patients with Primary Biliary Cholangitis.Clonal Characteristics of Paired Infiltrating and Circulating B Lymphocyte Repertoire in Patients with Primary Biliary Cholangitis. Liver Int. 2017 Aug 19;: Authors: Tan YG, Wang XF, Zhang M, Zhang HP, Wang YQ, Yu XQ, Liao HY, Wang YP, Lv FD, Lin DD, Yan HP, Gao ZH Abstract BACKGROUND: PBC is a prototypical autoimmune liver disease…
Autoimmune Hepatitis with Autoimmune Haemolytic Anemia Triggered by Varicella - a Rare Presentation.Related Articles Autoimmune Hepatitis with Autoimmune Haemolytic Anemia Triggered by Varicella - a Rare Presentation. Maedica (Buchar). 2016 Dec;11(4):349-351 Authors: Jain D, Singh H, Singh G, Jain P Abstract Varicella is a common infectious exanthematous disease of children. Infection manifests as polymorphic maculopapulovesicular along with low grade fever, malaise and headache. Adults are less likely…
Serum microRNA profiles in patients with chronic hepatitis B, chronic hepatitis C, primary biliary cirrhosis, autoimmune hepatitis, nonalcoholic steatohepatitis, or drug-induced liver injury.Serum microRNA profiles in patients with chronic hepatitis B, chronic hepatitis C, primary biliary cirrhosis, autoimmune hepatitis, nonalcoholic steatohepatitis, or drug-induced liver injury. Clin Biochem. 2017 Aug 17;: Authors: Yamaura Y, Tatsumi N, Takagi S, Tokumitsu S, Fukami T, Tajiri K, Minemura M, Yokoi T, Nakajima M Abstract PURPOSE: Some blood biomarkers or histological examination…
Seropositivity and Titers of Anti-Smooth Muscle Actin Antibody Are Associated with Relapse of Type 1 Autoimmune Hepatitis.Seropositivity and Titers of Anti-Smooth Muscle Actin Antibody Are Associated with Relapse of Type 1 Autoimmune Hepatitis. Med Sci Monit. 2017 Aug 20;23:4028-4033 Authors: Shibuki T, Otsuka T, Isoda H, Araki N, Kubotsu Y, Kawaguchi Y, Nakashita S, Yoshioka W, Kawazoe S, Kawasoe H, Ide Y, Mizuta T, Liver Diseases Sasld SSGO Abstract BACKGROUND It…
PPAR agonists for primary biliary cholangitis.PPAR agonists for primary biliary cholangitis. Lancet Gastroenterol Hepatol. 2017 Aug 14;: Authors: Gossard AA, Gores GJ PMID: 28818517 [PubMed - as supplied by publisher]
Efficacy and Safety of Durvalumab in Locally Advanced or Metastatic Urothelial Carcinoma: Updated Results From a Phase 1/2 Open-label Study.Efficacy and Safety of Durvalumab in Locally Advanced or Metastatic Urothelial Carcinoma: Updated Results From a Phase 1/2 Open-label Study. JAMA Oncol. 2017 Aug 17;:e172411 Authors: Powles T, O'Donnell PH, Massard C, Arkenau HT, Friedlander TW, Hoimes CJ, Lee JL, Ong M, Sridhar SS, Vogelzang NJ, Fishman MN, Zhang J, Srinivas S, Parikh J, Antal…
A combined bile and urine proteomic test for cholangiocarcinoma diagnosis in patients with biliary strictures of unknown origin.Related Articles A combined bile and urine proteomic test for cholangiocarcinoma diagnosis in patients with biliary strictures of unknown origin. United European Gastroenterol J. 2017 Aug;5(5):668-676 Authors: Voigtländer T, Metzger J, Schönemeier B, Jäger M, Mischak H, Manns MP, Lankisch TO Abstract BACKGROUND: Detection of cholangiocarcinoma (CC) remains a diagnostic challenge particularly in patients with…
Sodium butyrate ameliorates S100/FCA-induced autoimmune hepatitis through regulation of intestinal tight junction and toll-like receptor signaling pathway.Related Articles Sodium butyrate ameliorates S100/FCA-induced autoimmune hepatitis through regulation of intestinal tight junction and toll-like receptor signaling pathway. Immunol Lett. 2017 Aug 12;: Authors: Wu JL, Zou JY, Hu ED, Chen DZ, Chen L, Lu FB, Xu LM, Zheng MH, Li H, Huang Y, Jin XY, Gong YW, Lin Z, Wang XD, Zhao MF,…
Validation of the Simplified Criteria for the Diagnosis of Autoimmune Hepatitis in Chilean-Hispanic Patients.Related Articles Validation of the Simplified Criteria for the Diagnosis of Autoimmune Hepatitis in Chilean-Hispanic Patients. Ann Hepatol. 2017 Aug 08;16(5):772-779 Authors: Candia R, Norero B, Agu Ero C, Díaz L, Ortega JP, Wolff R, Hernández-Rocha C, Duarte I, Soza A, Benítez C, Arrese M Abstract INTRODUCTION AND AIM: In 2008 the International autoimmune hepatitis…
Fibrates for Primary Biliary Cholangitis: What's All the Hype?Related Articles Fibrates for Primary Biliary Cholangitis: What's All the Hype? Ann Hepatol. 2017 Aug 08;16(5):704-706 Authors: Levy C Abstract Ursodeoxycholic acid is the first-line therapy for primary biliary cholangitis. However, a subset of patients fail to show biochemical response. For these patients, adjuvant therapies are warranted. Obeticholic acid was conditionally approved as a second-line…
Assessment of Pharmacokinetic Interactions Between Obeticholic Acid and Caffeine, Midazolam, Warfarin, Dextromethorphan, Omeprazole, Rosuvastatin, and Digoxin in Phase 1 Studies in Healthy Subjects.Related Articles Assessment of Pharmacokinetic Interactions Between Obeticholic Acid and Caffeine, Midazolam, Warfarin, Dextromethorphan, Omeprazole, Rosuvastatin, and Digoxin in Phase 1 Studies in Healthy Subjects. Adv Ther. 2017 Aug 14;: Authors: Edwards JE, Eliot L, Parkinson A, Karan S, MacConell L Abstract INTRODUCTION: Obeticholic acid (OCA), a potent and selective farnesoid X receptor agonist, is…
Rapidly progressive atherosclerosis after domino liver transplantation from a teenage donor with homozygous familial hypercholesterolemia.Related Articles Rapidly progressive atherosclerosis after domino liver transplantation from a teenage donor with homozygous familial hypercholesterolemia. J Clin Lipidol. 2017 Jul 22;: Authors: Golbus JR, Farhat L, Fontana RJ, Rubenfire M Abstract Familial hypercholesterolemia (FH) is an autosomal dominant disorder characterized by impaired clearance of low-density lipoprotein cholesterol. Given limitations in pharmacologic therapy and…
Circulating follicular helper T cells presented distinctively different responses toward bacterial antigens in primary biliary cholangitis.Circulating follicular helper T cells presented distinctively different responses toward bacterial antigens in primary biliary cholangitis. Int Immunopharmacol. 2017 Aug 11;51:76-81 Authors: Zhou ZQ, Tong DN, Guan J, Li MF, Feng QM, Zhou MJ, Zhang ZY Abstract Primary biliary cholangitis (PBC) is a chronic and progressive cholestatic liver disease with unknown causes. The initiation of…
Primary sclerosing cholangitis - a comprehensive review.Related Articles Primary sclerosing cholangitis - a comprehensive review. J Hepatol. 2017 Aug 09;: Authors: Karlsen TH, Folseraas T, Thorburn D, Vesterhus M Abstract Primary sclerosing cholangitis (PSC) is a rare disorder characterized by multi-focal bile duct strictures and progressive liver disease. Inflammatory bowel disease (IBD) is usually present and there is a high risk…
Targeting senescent cholangiocytes and activated fibroblasts with Bcl-xL inhibitors ameliorates fibrosis in Mdr2(-/-) mice.Targeting senescent cholangiocytes and activated fibroblasts with Bcl-xL inhibitors ameliorates fibrosis in Mdr2(-/-) mice. Hepatology. 2017 Aug 12;: Authors: Moncsek A, Al-Suraih MS, Trussoni CE, O'Hara SP, Splinter PL, Zuber C, Patsenker E, Valli PV, Fingas CD, Weber A, Zhu Y, Tchkonia T, Kirkland JL, Gores GJ, Müllhaupt B, LaRusso NF, Mertens JC Abstract Cholangiocyte…
Gut microbial profile in primary biliary cholangitis: Towards bioindicators.Related Articles Gut microbial profile in primary biliary cholangitis: Towards bioindicators. Clin Res Hepatol Gastroenterol. 2017 Aug 07;: Authors: Lemoinne S, Marteau P PMID: 28797907 [PubMed - as supplied by publisher]
Inflammatory Bowel Disease with Primary Sclerosing Cholangitis: a Danish Population-based Cohort Study 1977-2011.Inflammatory Bowel Disease with Primary Sclerosing Cholangitis: a Danish Population-based Cohort Study 1977-2011. Liver Int. 2017 Aug 10;: Authors: Sørensen JØ, Nielsen OH, Andersson M, Ainsworth MA, Ytting H, Bélard E, Jess T Abstract BACKGROUND AND AIMS: Inflammatory bowel disease (IBD) may be complicated by primary sclerosing cholangitis (PSC). We aimed to assess the characteristics…
Genetic variation at the CD28 locus and its impact on expansion of pro-inflammatory CD28 negative T cells in healthy individuals.Related Articles Genetic variation at the CD28 locus and its impact on expansion of pro-inflammatory CD28 negative T cells in healthy individuals. Sci Rep. 2017 Aug 09;7(1):7652 Authors: Liaskou E, Jeffery L, Chanouzas D, Soskic B, Seldin MF, Harper L, Sansom D, Hirschfield GM Abstract The CD28 locus is associated with susceptibility to a variety…
Bile microbiota in primary sclerosing cholangitis: Impact on disease progression and development of biliary dysplasia.Bile microbiota in primary sclerosing cholangitis: Impact on disease progression and development of biliary dysplasia. PLoS One. 2017;12(8):e0182924 Authors: Pereira P, Aho V, Arola J, Boyd S, Jokelainen K, Paulin L, Auvinen P, Färkkilä M Abstract OBJECTIVE: The etiopathogenesis and risk for development of biliary neoplasia in primary sclerosing cholangitis (PSC) are largely unknown. Microbes…
Chronic Autoimmune Epithelitis in Sjögren's Syndrome and Primary Biliary Cholangitis: A Comprehensive Review.Related Articles Chronic Autoimmune Epithelitis in Sjögren's Syndrome and Primary Biliary Cholangitis: A Comprehensive Review. Rheumatol Ther. 2017 Aug 08;: Authors: Selmi C, Gershwin ME Abstract Within the spectrum of autoimmune diseases, Sjögren's syndrome and primary biliary cholangitis are exemplary and can be coined as chronic epithelitis based on their frequent coexistence in clinical practice…
New approach to decrease post-ERCP adverse events in patients with primary sclerosing cholangitis.Related Articles New approach to decrease post-ERCP adverse events in patients with primary sclerosing cholangitis. Endosc Int Open. 2017 Aug;5(8):E710-E717 Authors: Navaneethan U, Lourdusamy D, Gutierrez NG, Zhu X, Vargo JJ, Parsi MA Abstract BACKGROUND AND STUDY AIMS : Endoscopic retrograde cholangiopancreatography (ERCP) is often performed in patients with primary sclerosing cholangitis (PSC). Our aim was…
Liver Fluke-Associated Biliary Tract Cancer.Related Articles Liver Fluke-Associated Biliary Tract Cancer. Gut Liver. 2017 Aug 09;: Authors: Prueksapanich P, Piyachaturawat P, Aumpansub P, Ridtitid W, Chaiteerakij R, Rerknimitr R Abstract Cholangiocarcinoma (CCA) is an aggressive cancer arising from epithelial cells of the bile duct. Most patients with CCA have an unresectable tumor at the time of diagnosis. In Western…
On the role of IgG4 in inflammatory conditions: lessons for IgG4-related disease.On the role of IgG4 in inflammatory conditions: lessons for IgG4-related disease. Biochim Biophys Acta. 2017 Aug 03;: Authors: Trampert DC, Hubers LM, van de Graaf SFJ, Beuers U Abstract The pathophysiology of immunoglobulin G4-related disease (IgG4-RD) and its most common manifestations, IgG4-associated (sclerosing) cholangitis and autoimmune pancreatitis, remains largely unknown, but IgG4 is presumably…
6-thioguanine is a safe and effective second-line treatment for autoimmune hepatitis.6-thioguanine is a safe and effective second-line treatment for autoimmune hepatitis. Clin Gastroenterol Hepatol. 2017 Aug 03;: Authors: Legué C, Legros L, Kammerer-Jacquet S, Jézequel C, Houssel-Debry P, Uguen T, Le Lan C, Guillygomarc'h A, Moirand R, Turlin B, Guyader D, Bardou-Jacquet E PMID: 28782666 [PubMed - as supplied by publisher]
Histological Changes in Autoimmune Hepatitis with Graves' Disease: A Child Case Report.Related Articles Histological Changes in Autoimmune Hepatitis with Graves' Disease: A Child Case Report. Intern Med. 2017 Aug 01;: Authors: Yamada M, Shibata H, Masugi Y, Ishi T, Kameyama K, Ebinuma H, Hasegawa T Abstract We herein report a child case of autoimmune hepatitis (AIH) accompanied with Graves' disease. Elevated aminotransferase levels were found in…
Genetic association analysis identifies variants associated with disease progression in primary sclerosing cholangitis.Related Articles Genetic association analysis identifies variants associated with disease progression in primary sclerosing cholangitis. Gut. 2017 Aug 04;: Authors: Alberts R, de Vries EMG, Goode EC, Jiang X, Sampaziotis F, Rombouts K, Böttcher K, Folseraas T, Weismüller TJ, Mason AL, Wang W, Alexander G, Alvaro D, Bergquist A, Björkström NK, Beuers U, Björnsson E,…
The functional characteristics CCNI modulation of myeloid- derived suppressor cells in liver inflammation.The functional characteristics CCNI modulation of myeloid- derived suppressor cells in liver inflammation. Hepatology. 2017 Aug 04;: Authors: Zhang H, Lian M, Zhang J, Bian Z, Tang R, Miao Q, Peng Y, Fang J, You Z, Invernizzi P, Wang Q, Gershwin ME, Ma X Abstract There is increasing awareness of the immunologic roles of liver…
Acute liver failure induced by idiosyncratic reaction to drugs: challenges in diagnosis and therapy.Related Articles Acute liver failure induced by idiosyncratic reaction to drugs: challenges in diagnosis and therapy. Liver Int. 2017 Aug 03;: Authors: Tujios SR, Lee WM Abstract Acute liver failure (ALF) requires urgent attention to identify etiology and determine prognosis, in order to assess likelihood of survival or need for transplantation. Identifying idiosyncratic drug-induced liver…
Lymphocytic hidradenitis: A distinctive histopathological finding of annular erythema of Sjögren syndrome.Related Articles Lymphocytic hidradenitis: A distinctive histopathological finding of annular erythema of Sjögren syndrome. Australas J Dermatol. 2017 Aug 03;: Authors: Hsu HC, Lin CY, Shih IH, Shen SC Abstract BACKGROUND/OBJECTIVES: Lymphocytic hidradenitis is a non-specific histopathological feature observed in many dermatoses such as lupus erythematosus, morphea or scleroderma. When it occurs it is usually…
Population-based prevalence, incidence, and disease burden of autoimmune hepatitis in South Korea.Related Articles Population-based prevalence, incidence, and disease burden of autoimmune hepatitis in South Korea. PLoS One. 2017;12(8):e0182391 Authors: Kim BH, Choi HY, Ki M, Kim KA, Jang ES, Jeong SH Abstract BACKGROUND AND AIM: Little is known about population-based epidemiology and disease burden of autoimmune hepatitis (AIH). The aim of this study was to investigate…
Annexin A11 is targeted by IgG4 and IgG1 autoantibodies in IgG4-related disease.Related Articles Annexin A11 is targeted by IgG4 and IgG1 autoantibodies in IgG4-related disease. Gut. 2017 Aug 01;: Authors: Hubers LM, Vos H, Schuurman AR, Erken R, Oude Elferink RP, Burgering B, van de Graaf SFJ, Beuers U Abstract OBJECTIVE: Immunoglobulin G4-related disease (IgG4-RD) is a multiorgan immune-mediated disease that predominantly affects the biliary tract…
'Patients with Ulcerative Colitis and Primary Sclerosing Cholangitis Frequently Have Subclinical Inflammation in the Proximal Colon'.Related Articles 'Patients with Ulcerative Colitis and Primary Sclerosing Cholangitis Frequently Have Subclinical Inflammation in the Proximal Colon'. Clin Gastroenterol Hepatol. 2017 Jul 26;: Authors: Cleveland NK, Rubin DT, Hart J, Weber CR, Meckel K, Tran AL, Aelvoet AS, Pan I, Gonsalves A, Gaetano JN, Williams K, Wroblewski K, Jabri B, Pekow J Abstract BACKGROUND…
Genetic determinants of cholangiopathies: molecular and systems genetics.Related Articles Genetic determinants of cholangiopathies: molecular and systems genetics. Biochim Biophys Acta. 2017 Jul 27;: Authors: Reichert MC, Hall RA, Krawczyk M, Lammert F Abstract Familial cholangiopathies are rare but potentially severe diseases. Their spectrum ranges from fairly benign conditions as, for example, benign recurrent intrahepatic cholestasis to low-phospholipid associated cholelithiasis and progressive familial…
The therapeutic effects of Yongdamsagan-tang on autoimmune hepatitis models.The therapeutic effects of Yongdamsagan-tang on autoimmune hepatitis models. Biomed Pharmacother. 2017 Jul 29;94:244-255 Authors: Park J, Kim H, Lee IS, Kim KH, Kim Y, Na YC, Lee JH, Jang HJ Abstract Autoimmune hepatitis (AIH) is an immunity disorder that is the result of antibodies in the liver tissue of the patient that are attacked…
Seronegative Autoimmune Hepatitis A Clinically Challenging Difficult Diagnosis.Related Articles Seronegative Autoimmune Hepatitis A Clinically Challenging Difficult Diagnosis. Case Rep Med. 2017;2017:3516234 Authors: Sherigar JM, Yavgeniy A, Guss D, Ngo N, Mohanty S Abstract Autoimmune hepatitis (AIH) is a complex liver disease of unknown cause which results in immune-mediated liver injury with varied clinical presentations. Seronegative AIH follows a similar course to autoantibody-positive…
Pathogenesis of Biliary Fibrosis.Related Articles Pathogenesis of Biliary Fibrosis. Biochim Biophys Acta. 2017 Jul 25;: Authors: Pinzani M, Luong TV Abstract Chronic cholestatic liver diseases such as primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC) are associated with active hepatic fibrogenesis, and, ultimately, to the development of cirrhosis. However, the precise relationship between cholestasis, in its broad…
Lymphangioleiomyomatosis, multifocal micronodular pneumocyte hyperplasia, and sarcoidosis: more pathological findings in the same chest CT, or a single pathological pathway?Related Articles Lymphangioleiomyomatosis, multifocal micronodular pneumocyte hyperplasia, and sarcoidosis: more pathological findings in the same chest CT, or a single pathological pathway? BMC Pulm Med. 2017 Jul 28;17(1):107 Authors: Di Marco F, Palumbo G, Terraneo S, Imeri G, Lesma E, Sverzellati N, Peron A, Gualandri L, Canevini MP, Centanni S Abstract BACKGROUND: Autoimmune hepatitis/primary biliary…
PARP2 deficiency affects invariant-NKT-cell maturation and protects mice from Concanavalin A-induced liver injury.Related Articles PARP2 deficiency affects invariant-NKT-cell maturation and protects mice from Concanavalin A-induced liver injury. Am J Physiol Gastrointest Liver Physiol. 2017 Jul 27;:ajpgi.00436.2016 Authors: Filliol A, Piquet-Pellorce C, Dion S, Genet V, Lucas-Clerc C, Dantzer F, Samson M Abstract Excessive or persistent inflammation and hepatocyte death are the key triggers of liver diseases. The…
Primary Biliary Cholangitis Alters Functional Connections of the Brain's Deep Gray Matter.Primary Biliary Cholangitis Alters Functional Connections of the Brain's Deep Gray Matter. Clin Transl Gastroenterol. 2017 Jul 27;8(7):e107 Authors: Mosher VAL, Swain MG, Pang JXQ, Kaplan GG, Sharkey KA, MacQueen GM, Goodyear BG Abstract OBJECTIVES: Fatigue, itch, depressed mood, and cognitive impairment significantly impact the quality of life of many patients with primary biliary cholangitis…
Underestimated Male Prevalence of Primary Biliary Cholangitis in China: Results of a 16-yr cohort study involving 769 patients.Related Articles Underestimated Male Prevalence of Primary Biliary Cholangitis in China: Results of a 16-yr cohort study involving 769 patients. Sci Rep. 2017 Jul 26;7(1):6560 Authors: Fan X, Wang T, Shen Y, Xi X, Yang L Abstract For primary biliary cholangitis (PBC), a sex ratio was reported to be significantly lower than previously cited in…
Polyparaneoplastic Manifestations of Malignant Thymoma: A Unique Case of Myasthenia, Autoimmune Hepatitis, Pure Red Cell Aplasia, and Keratoconjunctivitis Sicca.Related Articles Polyparaneoplastic Manifestations of Malignant Thymoma: A Unique Case of Myasthenia, Autoimmune Hepatitis, Pure Red Cell Aplasia, and Keratoconjunctivitis Sicca. Cureus. 2017 Jun 20;9(6):e1374 Authors: Feinsilber D, Mears KA, Pettiford BL Abstract Thymomas are relatively uncommon malignancies of the anterior mediastinum and present with four distinct histological types based on the specific epithelial to…
A novel prognostic model for transplant-free survival in primary sclerosing cholangitis.Related Articles A novel prognostic model for transplant-free survival in primary sclerosing cholangitis. Gut. 2017 Jul 24;: Authors: de Vries EM, Wang J, Williamson KD, Leeflang MM, Boonstra K, Weersma RK, Beuers U, Chapman RW, Geskus RB, Ponsioen CY Abstract OBJECTIVE: Most prognostic models for primary sclerosing cholangitis (PSC) are based on patients referred to…
Mogamulizumab-induced toxicoderma-like eruptions and autoimmune hepatitis successfully treated with azathioprine in adult T-cell leukaemia/lymphoma.Related Articles Mogamulizumab-induced toxicoderma-like eruptions and autoimmune hepatitis successfully treated with azathioprine in adult T-cell leukaemia/lymphoma. Eur J Dermatol. 2017 Jul 25;: Authors: Nishizawa A, Ishikawa T, Hirose M, Satoh H, Nishii S, Tomita K, Hokari R, Satoh T PMID: 28739547 [PubMed - as supplied by publisher]
Development of autoantibodies precedes clinical manifestations of autoimmune diseases: A comprehensive review.Related Articles Development of autoantibodies precedes clinical manifestations of autoimmune diseases: A comprehensive review. J Autoimmun. 2017 Jul 21;: Authors: Ma WT, Chang C, Gershwin ME, Lian ZX Abstract The etiology of autoimmune diseases is due to a combination of genetic predisposition and environmental factors that alter the expression of immune regulatory genes through various…
Histological remission of autoimmune hepatitis after the addition of allopurinol and azathioprine dose reduction.Related Articles Histological remission of autoimmune hepatitis after the addition of allopurinol and azathioprine dose reduction. Autops Case Rep. 2017 Apr-Jun;7(2):35-42 Authors: Guedes ALV, Andrade AR, Nunes VS, Lima FR, de Mello ES, Ono SK, Terrabuio DRB, Cançado ELR Abstract The standard therapy for some autoimmune diseases consists of a combination of corticosteroids and thiopurines.…
Distinct gut microbiota profiles in patients with primary sclerosing cholangitis and ulcerative colitis.Related Articles Distinct gut microbiota profiles in patients with primary sclerosing cholangitis and ulcerative colitis. World J Gastroenterol. 2017 Jul 07;23(25):4548-4558 Authors: Bajer L, Kverka M, Kostovcik M, Macinga P, Dvorak J, Stehlikova Z, Brezina J, Wohl P, Spicak J, Drastich P Abstract AIM: To characterize the gut bacterial microbiota of patients with primary sclerosing…
Anastrozole-induced Autoimmune Hepatitis: A Rare Complication of Breast Cancer Therapy.Related Articles Anastrozole-induced Autoimmune Hepatitis: A Rare Complication of Breast Cancer Therapy. Anticancer Res. 2017 Aug;37(8):4173-4176 Authors: Klapko O, Ghoulam E, Jakate S, Eswaran S, Usha L Abstract BACKGROUND: Autoimmune hepatitis (AIH) is an extremely rare complication of anastrozole therapy. It presents with elevated liver function tests. The diagnosis is established by detecting high titers…
Clinical usefulness of serum antibodies as biomarkers of gastrointestinal and liver diseases.Related Articles Clinical usefulness of serum antibodies as biomarkers of gastrointestinal and liver diseases. Dig Liver Dis. 2017 Jun 23;: Authors: Di Sabatino A, Biagi F, Lenzi M, Frulloni L, Lenti MV, Giuffrida P, Corazza GR Abstract The progressively growing knowledge of the pathophysiology of a number of immune-mediated gastrointestinal and liver disorders, including autoimmune…Cholangiocytes and the environment in primary sclerosing cholangitis: where is the link?Related Articles Cholangiocytes and the environment in primary sclerosing cholangitis: where is the link? Gut. 2017 Jul 21;: Authors: O'Hara SP, Karlsen TH, LaRusso NF PMID: 28733279 [PubMed - as supplied by publisher]
- Sequencing of FIC1, BSEP and MDR3 in a large cohort of patients with cholestasis revealed a high number of different genetic variants.Related Articles Sequencing of FIC1, BSEP and MDR3 in a large cohort of patients with cholestasis revealed a high number of different genetic variants. J Hepatol. 2017 Jul 18;: Authors: Dröge C, Bonus M, Baumann U, Klindt C, Lainka E, Kathemann S, Brinkert F, Grabhorn E, Pfister ED, Wenning D, Fichtner A, Gotthardt DN, Weiss…
Autoimmune Liver Disease in Children with Sickle Cell Disease.Related Articles Autoimmune Liver Disease in Children with Sickle Cell Disease. J Pediatr. 2017 Jul 20;: Authors: Jitraruch S, Fitzpatrick E, Deheragoda M, Deganello A, Mieli-Vergani G, Height S, Rees D, Hadzic N, Samyn M Abstract OBJECTIVE: To assess the incidence, clinical features, and outcome of autoimmune liver disease (AILD) in patients with sickle cell…
The diagnostic accuracy of biomarkers for diagnosis of primary biliary cholangitis (PBC) in anti-mitochondrial antibody (AMA)-negative PBC patients: a review of literature.The diagnostic accuracy of biomarkers for diagnosis of primary biliary cholangitis (PBC) in anti-mitochondrial antibody (AMA)-negative PBC patients: a review of literature. Clin Chem Lab Med. 2017 Jul 21;: Authors: de Liso F, Matinato C, Ronchi M, Maiavacca R Abstract Primary biliary cholangitis (PBC), also known as primary biliary cirrhosis, is an autoimmune disease of…
Efficacy and safety of vedolizumab as a treatment option for moderate to severe refractory ulcerative colitis in two patients after liver transplant due to primary sclerosing cholangitis.Related Articles Efficacy and safety of vedolizumab as a treatment option for moderate to severe refractory ulcerative colitis in two patients after liver transplant due to primary sclerosing cholangitis. Rev Esp Enferm Dig. 2017 Jul 14;109: Authors: Olmedo Martín RV, Amo Trillo V, González Grande R, Jiménez Pérez M Abstract Vedolizumab is a humanized IgG1…
Anti-mitochondrial M2 Antibodies Enhance the Risk of Supraventricular Arrhythmias in Patients with Elevated Hepatobiliary Enzyme Levels.Related Articles Anti-mitochondrial M2 Antibodies Enhance the Risk of Supraventricular Arrhythmias in Patients with Elevated Hepatobiliary Enzyme Levels. Intern Med. 2017;56(14):1771-1779 Authors: Konishi H, Fukuzawa K, Mori S, Satomi-Kobayashi S, Kiuchi K, Suzuki A, Yano Y, Yoshida A, Hirata KI Abstract Objective Supraventricular arrhythmias are commonly detected in patients with anti-mitochondrial antibody M2 (AMA-M2)-associated myopathy.…
IgG4-related disease: long-term natural history and management of a relapsing multisystem disease entity.Related Articles IgG4-related disease: long-term natural history and management of a relapsing multisystem disease entity. BMJ Case Rep. 2017 Jul 16;2017: Authors: Kotha S, Tritto G, Wong T, Berry P Abstract Although awareness of IgG4-related disease has grown over the past decade, with earlier diagnosis and treatment, understanding of its natural history over the long…