Derniers articles listés par NCBI PubMed sur les maladies inflammatoires du foie et des voies biliaires (en anglais)
Qu’est-ce que PubMed?
Pubmed est la Bibliothèque Nationale de Médecine américaine. Pubmed incorpore plus de 24 millions d’extraits de littérature biomédicale issus du service en ligne MEDLINE, de journaux et livres scientifiques. Les extraits incorporent parfois des liens vers les textes intégraux des articles ou vers les sites web des éditeurs. Ces documents sont des publications scientifiques relatant l’avancée de la recherche sur les maladies inflammatoires du foie et des voies biliaires. Ils sont relayés ici sur le site d’albi afin que les malades comme les professionnels de la santé se fassent une idée des thématiques d’études et des avancées de la recherche. Il faut bien comprendre que ces communications sont des résultats de recherches ponctuelles, qui doivent être validés par d’autres études, pour éventuellement déboucher sur des innovations thérapeutiques quelques années plus tard. Si vous êtes malade, il est évident que ces informations ne peuvent pas être prises en compte pour prendre l’initiative d’une quelconque modification de votre traitement, modification qui ne peut se faire que sous avis médical.
What is PubMed?
PubMed is the US National Library of Medicine. PubMed comprises more than 24 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
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Prolonged darkness reduces liver fibrosis in a mouse model of primary sclerosing cholangitis by miR-200b down-regulation.Related Articles Prolonged darkness reduces liver fibrosis in a mouse model of primary sclerosing cholangitis by miR-200b down-regulation. FASEB J. 2017 Jun 20;: Authors: Wu N, Meng F, Zhou T, Han Y, Kennedy L, Venter J, Francis H, DeMorrow S, Onori P, Invernizzi P, Bernuzzi F, Mancinelli R, Gaudio E, Franchitto A, Glaser S, Alpini…
Dermatitis Herpetiformis as the Initial Presentation of Primary Biliary Cholangitis in a Male with Gluten Sensitivity.Related Articles Dermatitis Herpetiformis as the Initial Presentation of Primary Biliary Cholangitis in a Male with Gluten Sensitivity. Cureus. 2017 May 14;9(5):e1247 Authors: Philips C, Paramaguru R, Indiran DA, Augustine P Abstract Celiac disease is commonly associated with elevated liver enzymes that normalize on a gluten-free diet. Celiac disease is rarely described in patients with…
Interactions between primary sclerosing cholangitis and inflammatory bowel disease: implications in the adult liver transplant setting.Interactions between primary sclerosing cholangitis and inflammatory bowel disease: implications in the adult liver transplant setting. Expert Rev Gastroenterol Hepatol. 2017 Jun 19;: Authors: Liu K, Strasser SI, Koorey DJ, Leong RW, Solomon M, McCaughan GW Abstract INTRODUCTION: Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease which is associated with inflammatory bowel disease…
Successful Treatment for Chronic Hepatitis C-Autoimmune Hepatitis Overlap Syndrome due to Daclatasvir and Asunaprevir.Related Articles Successful Treatment for Chronic Hepatitis C-Autoimmune Hepatitis Overlap Syndrome due to Daclatasvir and Asunaprevir. Case Rep Gastroenterol. 2017 May-Aug;11(2):305-311 Authors: Sugiura A, Wada S, Mori H, Kimura T, Matsuda Y, Tanaka N, Tanaka E, Kiyosawa K Abstract Persistent hepatitis C virus (HCV) infection may induce autoimmune diseases and chronic hepatitis C is sometimes…
Recurrence of primary sclerosing cholangitis, primary biliary cholangitis and auto-immune hepatitis after liver transplantation.Recurrence of primary sclerosing cholangitis, primary biliary cholangitis and auto-immune hepatitis after liver transplantation. Best Pract Res Clin Gastroenterol. 2017 Apr;31(2):187-198 Authors: Visseren T, Darwish Murad S Abstract Liver transplantation is a well-accepted treatment for decompensated chronic liver disease due to primary sclerosing cholangitis (PSC), primary biliary cholangitis (PBC) and auto-immune hepatitis (AIH). Survival after…
Hepatic stroma-educated regulatory DCs suppress CD8+ T cell proliferation in mice.Related Articles Hepatic stroma-educated regulatory DCs suppress CD8+ T cell proliferation in mice. Oncotarget. 2017 Jun 13;: Authors: Wang Q, He H, Chen D, Wang C, Xu Y, Song W Abstract Liver dendritic cells (DCs) display immunosuppressive activities and inhibit the CD4+ T cell response. The present study assessed whether and how liver DCs suppress…
Intraductal papillary neoplasia of the bile duct with malignancy: A differentiated entity of cholangiocarcinoma with a better prognosis, a review of three new cases.Intraductal papillary neoplasia of the bile duct with malignancy: A differentiated entity of cholangiocarcinoma with a better prognosis, a review of three new cases. Rev Esp Enferm Dig. 2017 Jun 15;109: Authors: Pérez Saborido B, Bailón Cuadrado M, Rodríguez López M, Asensio Díaz E, Madrigal Rubiales B, Barrera Rebollo A Abstract INTRODUCTION: Intraductal papillary neoplasms…
Incidence, prevalence, and natural history of primary sclerosing cholangitis in the United Kingdom.Incidence, prevalence, and natural history of primary sclerosing cholangitis in the United Kingdom. Medicine (Baltimore). 2017 Jun;96(24):e7116 Authors: Liang H, Manne S, Shick J, Lissoos T, Dolin P Abstract Primary sclerosing cholangitis (PSC) is a rare obliterative fibrotic condition of the bile ducts. We assessed PSC epidemiology and natural history within the UK Clinical Practice…
The Almost-normal Liver Biopsy: Presentation, Clinical Associations, and Outcome.The Almost-normal Liver Biopsy: Presentation, Clinical Associations, and Outcome. Am J Surg Pathol. 2017 Jun 13;: Authors: Czeczok TW, Van Arnam JS, Wood LD, Torbenson MS, Mounajjed T Abstract Liver biopsies obtained for abnormal liver enzymes or unexplained ascites occasionally appear histologically almost normal. The differential diagnosis for these cases is challenging because literature addressing…
Primary sclerosing cholangitis: Ursodeoxycholic acid derivative: safe and effective.Related Articles Primary sclerosing cholangitis: Ursodeoxycholic acid derivative: safe and effective. Nat Rev Gastroenterol Hepatol. 2017 Jun 14;: Authors: Dickson I PMID: 28611476 [PubMed - as supplied by publisher]
Prevalence, Risk Factors, and Survival of Patients with Intrahepatic Cholangiocarcinoma.Related Articles Prevalence, Risk Factors, and Survival of Patients with Intrahepatic Cholangiocarcinoma. Ann Hepatol. 2017 Aug 01;16(4):565-568 Authors: Chinchilla-López P, E Aguilar-Olivos N, García-Gómez J, K Hernández-Alejandro K, Chablé-Montero F, Motola-Kuba D, Patel T, Mendez-Sánchez N Abstract PURPOSE: To investigate the prevalence, related risk factors, and survival of intrahepatic cholangiocarcinoma in a Mexican population. MATERIAL…
Autoimmune Hepatitis: Factors Involved in Initiation and Methods of Diagnosis and Treatment.Related Articles Autoimmune Hepatitis: Factors Involved in Initiation and Methods of Diagnosis and Treatment. Crit Rev Immunol. 2016;36(5):407-428 Authors: Lauletta G, Russi S, Pavone F, Marzullo A, Tampoia M, Sansonno D, Dammacco F Abstract Autoimmune hepatitis is an acute or mostly chronic liver disease that can affect both adults and children and has a clear…
The challenge of cholangiocarcinoma diagnosis: the turning point is in extracellular vesicles?The challenge of cholangiocarcinoma diagnosis: the turning point is in extracellular vesicles? Hepatology. 2017 Jun 12;: Authors: Alvaro D PMID: 28605030 [PubMed - as supplied by publisher]
Efficacy and Safety of Mycophenolate Mofetil and Tacrolimus as Second-line Therapy for Patients with Autoimmune Hepatitis.Related Articles Efficacy and Safety of Mycophenolate Mofetil and Tacrolimus as Second-line Therapy for Patients with Autoimmune Hepatitis. Clin Gastroenterol Hepatol. 2017 Jun 08;: Authors: Efe C, Hagström H, Ytting H, Bhanji RA, Müller NF, Wang Q, Purnak T, Muratori L, Werner M, Marschall HU, Muratori P, Gunşar F, Klintman D, Parés A, Heurgué-Berlot A,…
Coexistent primary biliary cholangitis with CREST syndrome (Reynold's syndrome).Related Articles Coexistent primary biliary cholangitis with CREST syndrome (Reynold's syndrome). Am J Med. 2017 Jun 08;: Authors: Kiyani A, Ursu S PMID: 28602872 [PubMed - as supplied by publisher]
Association between primary biliary cholangitis and fracture: A meta-analysis.Related Articles Association between primary biliary cholangitis and fracture: A meta-analysis. Clin Res Hepatol Gastroenterol. 2017 Jun 08;: Authors: Zhao J, Li W, Cao J, Liang C, Yao DK PMID: 28602798 [PubMed - as supplied by publisher]
Inhibition of microRNA-24 increases liver fibrosis by enhanced menin expression in Mdr2(-/-) mice.Related Articles Inhibition of microRNA-24 increases liver fibrosis by enhanced menin expression in Mdr2(-/-) mice. J Surg Res. 2017 May 11;: Authors: Hall C, Ehrlich L, Meng F, Invernizzi P, Bernuzzi F, Lairmore TC, Alpini G, Glaser S Abstract BACKGROUND: Liver transplantation remains the primary treatment for primary sclerosing cholangitis (PSC). Mdr2(-/-) mice provide a…
Treg Conditioning Endows Activated Teff with Suppressor Function in Autoimmune Hepatitis/Autoimmune Sclerosing Cholangitis.Treg Conditioning Endows Activated Teff with Suppressor Function in Autoimmune Hepatitis/Autoimmune Sclerosing Cholangitis. Hepatology. 2017 Jun 09;: Authors: Liberal R, Grant CR, Yuksel M, Graham J, Kalbasi A, Ma Y, Heneghan MA, Mieli-Vergani G, Vergani D, Longhi MS Abstract Imbalance between T regulatory (Treg) and T effector (Teff) cells is likely to contribute to induction…
Branched chain α-ketoacid dehydrogenase kinase 111-130, a T cell epitope that induces both autoimmune myocarditis and hepatitis in A/J mice.Related Articles Branched chain α-ketoacid dehydrogenase kinase 111-130, a T cell epitope that induces both autoimmune myocarditis and hepatitis in A/J mice. Immun Inflamm Dis. 2017 Jun 09;: Authors: Krishnan B, Massilamany C, Basavalingappa RH, Gangaplara A, Kang G, Li Q, Uzal FA, Strande JL, Delhon GA, Riethoven JJ, Steffen D, Reddy J Abstract INTRODUCTION:…
Recent advances in the management of pruritus in chronic liver diseases.Related Articles Recent advances in the management of pruritus in chronic liver diseases. World J Gastroenterol. 2017 May 21;23(19):3418-3426 Authors: Tajiri K, Shimizu Y Abstract Pruritus is a symptom found in patients with chronic liver diseases, especially cholestatic liver diseases such as primary biliary cholangitis. This symptom impairs patient quality of life by disturbing sleep…
Crosstalk between type II NKT cells and T cells leads to spontaneous chronic inflammatory liver disease.Related Articles Crosstalk between type II NKT cells and T cells leads to spontaneous chronic inflammatory liver disease. J Hepatol. 2017 Jun 05;: Authors: Weng X, He Y, Visvabharathy L, Liao CM, Tan X, Balakumar A, Wang CR Abstract BACKGROUND & AIM: NKT cells are CD1d-restricted innate-like T cells that modulate innate and adaptive immune…
Parameters of ventricular repolarization in patients with autoimmune hepatitis.Parameters of ventricular repolarization in patients with autoimmune hepatitis. Turk Kardiyol Dern Ars. 2017 Jun;45(4):333-338 Authors: Açar B, Yüksel M, Yayla Ç, Kırbaş Ö, Ünal S, Ertem AG, Demirtaş K, Kaplan M, Akdoğan M, Kaçar S, Kayaçetin E, Aydoğdu S Abstract OBJECTIVE: Autoimmune hepatitis (AIH) is a liver disorder that affects both children and adults.…
Hyperferritinemia and hypergammaglobulinemia predict the treatment response to standard therapy in autoimmune hepatitis.Hyperferritinemia and hypergammaglobulinemia predict the treatment response to standard therapy in autoimmune hepatitis. PLoS One. 2017;12(6):e0179074 Authors: Taubert R, Hardtke-Wolenski M, Noyan F, Lalanne C, Jonigk D, Schlue J, Krech T, Lichtinghagen R, Falk CS, Schlaphoff V, Bantel H, Muratori L, Manns MP, Jaeckel E Abstract Autoimmune hepatitis (AIH) is a chronic hepatitis with an…
Identification of the functional variant driving ORMDL3 and GSDMB expression in human chromosome 17q12-21 in primary biliary cholangitis.Related Articles Identification of the functional variant driving ORMDL3 and GSDMB expression in human chromosome 17q12-21 in primary biliary cholangitis. Sci Rep. 2017 Jun 06;7(1):2904 Authors: Hitomi Y, Kojima K, Kawashima M, Kawai Y, Nishida N, Aiba Y, Yasunami M, Nagasaki M, Nakamura M, Tokunaga K Abstract Numerous genome-wide association studies (GWAS) have been performed…
Primary Sclerosing Cholangitis in a Young Female.Related Articles Primary Sclerosing Cholangitis in a Young Female. Mymensingh Med J. 2017 Apr;26(2):455-458 Authors: Biswas S, Bala CS, Ahasan MN, Chowdhury MK, Hassan MM, Sarkar PK, Sarkar MM, Haque M Abstract Primary sclerosing cholangitis (PSC) is a liver disease characterized by inflammation and fibrosis of both intrahepatic and extrahepatic bile ducts resulting in cholestasis.…
Comparison of in silico prediction and experimental assessment of ABCB4 variants identified in patients with biliary diseases.Related Articles Comparison of in silico prediction and experimental assessment of ABCB4 variants identified in patients with biliary diseases. Int J Biochem Cell Biol. 2017 Jun 03;: Authors: Khabou B, Durand-Schneider AM, Delaunay JL, Aït-Slimane T, Barbu V, Fakhfakh F, Housset C, Maurice M Abstract Genetic variations of the phosphatidylcholine transporter, ABCB4 cause several biliary…
Primary sclerosing cholangitis associated with severe ulcerative colitis in a young man.Related Articles Primary sclerosing cholangitis associated with severe ulcerative colitis in a young man. Autops Case Rep. 2013 Oct-Dec;3(4):37-41 Authors: Xavier JCC, Coelho KIR, Sassaki LY, Yamashiro FDS, Oliveira KCL, Rodrigues MAM Abstract Primary sclerosing cholangitis, a chronic progressive cholestatic liver disease, is the most serious hepatobiliary complication of ulcerative colitis (UC). The authors present…
Possible involvement of CCR7(-) PD-1(+) follicular helper T cell subset in the pathogenesis of autoimmune hepatitis.Possible involvement of CCR7(-) PD-1(+) follicular helper T cell subset in the pathogenesis of autoimmune hepatitis. J Gastroenterol Hepatol. 2017 Jun 07;: Authors: Kimura N, Yamagiwa S, Sugano T, Setsu T, Tominaga K, Kamimura H, Takamura M, Terai S Abstract BACKGROUND AND AIM: Recent studies have demonstrated that B cells and follicular helper T (Tfh)…
Elevated trimethylamine-N-oxide (TMAO) is associated with poor prognosis in primary sclerosing cholangitis patients with normal liver function.Related Articles Elevated trimethylamine-N-oxide (TMAO) is associated with poor prognosis in primary sclerosing cholangitis patients with normal liver function. United European Gastroenterol J. 2017 Jun;5(4):532-541 Authors: Kummen M, Vesterhus M, Trøseid M, Moum B, Svardal A, Boberg KM, Aukrust P, Karlsen TH, Berge RK, Hov JR Abstract BACKGROUND: Trimethylamine-N-oxide (TMAO) is produced in the liver…
Distinctive HLA-II association with primary biliary cholangitis on the Island of Sardinia.Related Articles Distinctive HLA-II association with primary biliary cholangitis on the Island of Sardinia. United European Gastroenterol J. 2017 Jun;5(4):527-531 Authors: Clemente MG, Frau F, Bernasconi M, Macis MD, Cicotto L, Pilleri G, De Virgiliis S, Castiglia P, Farci P Abstract BACKGROUND: The HLA DRB1*08 allele associated with primary biliary cholangitis (PBC) among Caucasians is…
Cytopenia first - hepatitis second: an unusual sequence in aplastic anemia.Related Articles Cytopenia first - hepatitis second: an unusual sequence in aplastic anemia. Clin Case Rep. 2017 Jun;5(6):778-781 Authors: Alashkar F, Föhring D, Dührsen U, Baba HA, Röth A Abstract To the best of our knowledge, this is the first report of aplastic anemia (AA) preceding autoantibody-negative autoimmune hepatitis (AIH) with successful treatment of both…
Steroid-resistant autoimmune myelofibrosis in a patient with autoimmune hepatitis and Evans syndrome complicated with increased expression of TGF-β in the bone marrow: a case report.Steroid-resistant autoimmune myelofibrosis in a patient with autoimmune hepatitis and Evans syndrome complicated with increased expression of TGF-β in the bone marrow: a case report. Int J Hematol. 2017 Jun 05;: Authors: Ohkawara H, Furukawa M, Ikeda K, Shichishima-Nakamura A, Fukatsu M, Sano T, Ueda K, Kimura S, Kanai R, Oka Y, Murakami F, Suzuki…
Metabolic profile of liver damage in non-cirrhotic virus C and autoimmune hepatitis: A proton decoupled (31)P-MRS study.Metabolic profile of liver damage in non-cirrhotic virus C and autoimmune hepatitis: A proton decoupled (31)P-MRS study. Eur J Radiol. 2017 May;90:205-211 Authors: Hakkarainen A, Puustinen L, Kivisaari R, Boyd S, Nieminen U, Arkkila P, Lundbom N Abstract PURPOSE: To study liver (31)P MRS, histology, transient elastography, and liver function tests in patients with virus…
Duct-to-duct Biliary Reconstruction in Living-donor Liver Transplantation for Primary Sclerosing Cholangitis: Report of a Case.Duct-to-duct Biliary Reconstruction in Living-donor Liver Transplantation for Primary Sclerosing Cholangitis: Report of a Case. Transplant Proc. 2017 Jun;49(5):1196-1198 Authors: Motomura T, Yoshizumi T, Wang H, Nagatsu A, Itoh S, Harada N, Harimoto N, Ikegami T, Uchiyama H, Soejima Y, Maehara Y Abstract Although Roux-en Y hepaticojejunostomy was previously recommended for the biliary reconstruction in…
Comparative Analysis of the Clinical Outcomes of Liver Transplantation for Probable and Definite Auto-immune Hepatitis by International Diagnostic Scoring Criteria.Comparative Analysis of the Clinical Outcomes of Liver Transplantation for Probable and Definite Auto-immune Hepatitis by International Diagnostic Scoring Criteria. Transplant Proc. 2017 Jun;49(5):1126-1128 Authors: Cho CW, Kwon CHD, Kim JM, Choi GS, Joh JW, Lee SK Abstract BACKGROUND: Liver transplantation (LT) is an effective treatment for patients with end-stage liver disease caused by auto-immune hepatitis…
The first case of domino-split-liver transplantation in maple syrup urine disease.The first case of domino-split-liver transplantation in maple syrup urine disease. Pediatr Transplant. 2017 Jun 05;: Authors: Herden U, Li J, Fischer L, Brinkert F, Blohm M, Santer R, Nashan B, Grabhorn E Abstract The enzymatic defect in MSUD results in accumulation of neurotoxic metabolites of BCAAs. LTX has shown to be a feasible strategy…
Resveratrol Pretreatment Attenuates Concanavalin A-induced Hepatitis through Reverse of Aberration in the Immune Response and Regenerative Capacity in Aged Mice.Resveratrol Pretreatment Attenuates Concanavalin A-induced Hepatitis through Reverse of Aberration in the Immune Response and Regenerative Capacity in Aged Mice. Sci Rep. 2017 Jun 02;7(1):2705 Authors: Huang TH, Chen CC, Liu HM, Lee TY, Shieh SH Abstract Loss of regenerative capacity plays a critical role in age-related autoimmune hepatitis. Evidence implicates SIRT1 and p66(shc) in…
The Importance of Liver-Fatty Acid Binding Protein in Diagnosis of Liver Damage in Patients with Acute Hepatitis.Related Articles The Importance of Liver-Fatty Acid Binding Protein in Diagnosis of Liver Damage in Patients with Acute Hepatitis. J Clin Diagn Res. 2017 Apr;11(4):OC17-OC21 Authors: Cakir OO, Toker A, Ataseven H, Demir A, Polat H Abstract INTRODUCTION: Acute hepatitis is acute inflammation of liver elicited by a large number of causes. It sometimes spontaneously…
Xanthoma Striatum Palmare in a Patient of Primary Biliary Cirrhosis with Autoimmune Hepatitis.Xanthoma Striatum Palmare in a Patient of Primary Biliary Cirrhosis with Autoimmune Hepatitis. Ann Dermatol. 2017 Jun;29(3):358-359 Authors: Yang MY, Kim JM, Kim GW, Kim HS, Kim BS, Kim MB, Ko HC PMID: 28566919 [PubMed]
Inflammatory bowel disease in liver transplanted patients.Inflammatory bowel disease in liver transplanted patients. World J Gastroenterol. 2017 May 14;23(18):3214-3227 Authors: Filipec Kanizaj T, Mijic M Abstract Most common hepatobiliary manifestation of inflammatory bowel disease (IBD) are primary sclerosing cholangitis (PSC) and autoimmune hepatitis, ranking them as the main cause of liver transplantation (LT) in IBD setting. Course of pre-existing IBD after…
Autoantibodies in antimithocondrial antibodies negative primary biliary cholangitis.Autoantibodies in antimithocondrial antibodies negative primary biliary cholangitis. Clin Res Hepatol Gastroenterol. 2017 May 26;: Authors: Muratori P, Muratori L PMID: 28566131 [PubMed - as supplied by publisher]
Epigenetics in the Primary Biliary Cholangitis and Primary Sclerosing Cholangitis.Epigenetics in the Primary Biliary Cholangitis and Primary Sclerosing Cholangitis. Semin Liver Dis. 2017 May;37(2):159-174 Authors: Cheung AC, LaRusso NF, Gores GJ, Lazaridis KN PMID: 28564724 [PubMed - in process]
Oral Vancomycin and Gentamicin for Treatment of Very Early Onset Inflammatory Bowel Disease.Oral Vancomycin and Gentamicin for Treatment of Very Early Onset Inflammatory Bowel Disease. Digestion. 2017 Jun 01;95(4):310-313 Authors: Lev-Tzion R, Ledder O, Shteyer E, Tan MLN, Uhlig HH, Turner D Abstract BACKGROUND: The pathogenesis of inflammatory bowel disease (IBD) is complex and involves the contribution of genetic and environmental factors. Many patients with very early…
Epidemiology and causes of death in a Swedish cohort of patients with autoimmune hepatitis.Epidemiology and causes of death in a Swedish cohort of patients with autoimmune hepatitis. Scand J Gastroenterol. 2017 May 31;:1-7 Authors: Danielsson Borssén Å, Marschall HU, Bergquist A, Rorsman F, Weiland O, Kechagias S, Nyhlin N, Verbaan H, Nilsson E, Werner M Abstract BACKGROUND: Epidemiological studies of autoimmune hepatitis (AIH) show varying figures on prevalence…
Identification of fucosylated Fetuin-A as a potential biomarker for cholangiocarcinoma.Identification of fucosylated Fetuin-A as a potential biomarker for cholangiocarcinoma. Proteomics Clin Appl. 2017 May 31;: Authors: Betesh L, Comunale MA, Wang M, Liang H, Hafner J, Karabudak A, Giama NH, Moser CD, Miyoshi E, Roberts LR, Block TM, Mehta A Abstract CLINICAL RELEVANCE: Cholangiocarcinoma is a cancer of bile duct cells for which no…
Long-term outcomes of de novo autoimmune hepatitis in pediatric liver transplant recipients.Long-term outcomes of de novo autoimmune hepatitis in pediatric liver transplant recipients. Pediatr Transplant. 2017 May 29;: Authors: Ekong UD, McKiernan P, Martinez M, Lobritto S, Kelly D, Ng VL, Alonso EM, Avitzur Y Abstract The long-term course and outcome of DAIH is unknown. A retrospective multicenter study assessing associations and long-term consequences of DAIH…
Recommendations on the use of MRI in PSC-A position statement from the International PSC study group.Recommendations on the use of MRI in PSC-A position statement from the International PSC study group. Hepatology. 2017 May 26;: Authors: Schramm C, Eaton J, Ringe KI, Venkatesh S, Yamamura J, MRI working group of the IPSCSG Abstract Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disorder characterized by inflammation and fibrosis of the…
Serum extracellular vesicles contain protein biomarkers for primary sclerosing cholangitis and cholangiocarcinoma.Serum extracellular vesicles contain protein biomarkers for primary sclerosing cholangitis and cholangiocarcinoma. Hepatology. 2017 May 26;: Authors: Arbelaiz A, Azkargorta M, Krawczyk M, Santos-Laso A, Lapitz A, Perugorria MJ, Erice O, Gonzalez E, Jimenez-Agüero R, Lacasta A, Ibarra C, Sanchez-Campos A, Jimeno JP, Lammert F, Milkiewicz P, Marzioni M, Macias RIR, Marin JJG, Patel T,…
Pentoxifylline attenuates cytokine stress and Fas system in syngeneic liver proteins induced experimental autoimmune hepatitis.Related Articles Pentoxifylline attenuates cytokine stress and Fas system in syngeneic liver proteins induced experimental autoimmune hepatitis. Biomed Pharmacother. 2017 May 25;92:316-323 Authors: Hendawy N Abstract BACKGROUND: Apoptosis is a hallmark in the pathogenesis of autoimmune hepatitis (AIH). Cytokine stresses and extrinsic apoptotic pathway have been implicated in this type of hepatic injury. Pentoxifylline plays…
Biliary-duodenal anastomosis using magnetic compression following massive resection of small intestine due to strangulated ileus after living donor liver transplantation: a case report.Related Articles Biliary-duodenal anastomosis using magnetic compression following massive resection of small intestine due to strangulated ileus after living donor liver transplantation: a case report. Surg Case Rep. 2017 Dec;3(1):73 Authors: Saito R, Tahara H, Shimizu S, Ohira M, Ide K, Ishiyama K, Kobayashi T, Ohdan H Abstract BACKGROUND: Despite the improvements of surgical techniques…
Primary Biliary Cholangitis: advances in management and treatment of the disease.Related Articles Primary Biliary Cholangitis: advances in management and treatment of the disease. Dig Liver Dis. 2017 May 08;: Authors: Invernizzi' P, Floreani A, Carbone M, Marzioni M, Craxi A, Muratori L, Vespasiani Gentilucci U, Gardini I, Gasbarrini A, Krugeri P, Mennini FS, Ronco V, Lanati E, Canonico PL, Alvaro D Abstract Primary Biliary Cholangitis,…
Role of fluorescence in situ hybridization in diagnosing cholangiocarcinoma in indeterminate biliary strictures.Related Articles Role of fluorescence in situ hybridization in diagnosing cholangiocarcinoma in indeterminate biliary strictures. J Gastroenterol Hepatol. 2017 May 19;: Authors: Liew ZH, Loh TJZ, Lim TKH, Lim TH, Khor CJL, Mesenas SJ, Kong CSC, Ong WC, Tan DMY Abstract BACKGROUND: Brush cytology, the conventional method to diagnose cholangiocarcinoma, has been plagued by low…
Drug-induced autoimmune hepatitis: response to corticosteroids and lack of relapse after cessation of steroids.Related Articles Drug-induced autoimmune hepatitis: response to corticosteroids and lack of relapse after cessation of steroids. Clin Gastroenterol Hepatol. 2017 May 20;: Authors: Björnsson E, Bergmann O, Jonasson JG, Grondal G, Gudbjornsson B, Olafsson S PMID: 28535988 [PubMed - as supplied by publisher]
Geoepidemiology, clinical manifestations and outcome of primary biliary cholangitis in Greece.Related Articles Geoepidemiology, clinical manifestations and outcome of primary biliary cholangitis in Greece. Eur J Intern Med. 2017 May 20;: Authors: Gatselis NK, Zachou K, Lygoura V, Azariadis K, Arvaniti P, Spyrou E, Papadamou G, Koukoulis GK, Dalekos GN, Rigopoulou EI Abstract BACKGROUND & AIMS: Primary biliary cholangitis (PBC) is a disease with rising prevalence…
Fibrates for the treatment of cholestatic itch (FITCH): study protocol for a randomized controlled trial.Related Articles Fibrates for the treatment of cholestatic itch (FITCH): study protocol for a randomized controlled trial. Trials. 2017 May 23;18(1):230 Authors: Bolier R, de Vries ES, Parés A, Helder J, Kemper EM, Zwinderman K, Elferink RPO, Beuers U, Netherlands Association for the Study of the Liver (NASL) Cholestatic Liver Diseases Study Group Abstract BACKGROUND:…
norUrsodeoxycholic Acid Improves Cholestasis in Primary Sclerosing Cholangitis.Related Articles norUrsodeoxycholic Acid Improves Cholestasis in Primary Sclerosing Cholangitis. J Hepatol. 2017 May 18;: Authors: Fickert P, Hirschfield GM, Denk G, Marschall HU, Altorjay I, Färkkilä M, Schramm C, Spengler U, Chapman R, Bergquist A, Schrumpf E, Nevens F, Trivedi P, Reiter FP, Tornai I, Halilbasic E, Greinwald R, Pröls M, Manns MP, Trauner…
Soluble Axl is an accurate biomarker of cirrhosis and hepatocellular carcinoma development: results from a large scale multicenter analysis.Related Articles Soluble Axl is an accurate biomarker of cirrhosis and hepatocellular carcinoma development: results from a large scale multicenter analysis. Oncotarget. 2017 May 03;: Authors: Dengler M, Staufer K, Huber H, Stauber R, Bantel H, Weiss KH, Starlinger P, Pock H, Klöters-Plachky P, Gotthardt DN, Rauch P, Lackner C, Stift J, Brostjan C, Gruenberger…
[Unusual association between auto-immune hepatitis and pyoderma gangrenosum. A case report].[Unusual association between auto-immune hepatitis and pyoderma gangrenosum. A case report]. Rev Med Brux. 2017;38(2):95-98 Authors: Vandemergel X, Lefebvre M, Focant I, Marot L, Ilisei D Abstract Pyoderma gangrenosum is an uncommon neutrophilic dermatosis that presents as an inflammatory and ulcerative disorder of the skin. This entity is associated with systemic diseases and autoimmune diseases…
Gastrointestinal system involvement in systemic lupus erythematosus.Gastrointestinal system involvement in systemic lupus erythematosus. Lupus. 2017 Jan 01;:961203317707825 Authors: Li Z, Xu D, Wang Z, Wang Y, Zhang S, Li M, Zeng X Abstract Systemic lupus erythematosus (SLE) is a multisystem disorder which can affect the gastrointestinal (GI) system. Although GI symptoms can manifest in 50% of patients with SLE, these have…
Autoimmune hepatitis with sclerosing cholangitis in a patient with thiopurine methyltransferase deficiency: case presentation.Related Articles Autoimmune hepatitis with sclerosing cholangitis in a patient with thiopurine methyltransferase deficiency: case presentation. Rom J Morphol Embryol. 2017;58(1):211-217 Authors: Man SC, Schnell CN, Sas V, Buzoianu AD, Gheban D Abstract The association between two autoimmune diseases is known in the literature as overlap syndrome. We present the case of an 18-year-old boy,…
Multiplex autoantibody detection for autoimmune liver diseases and autoimmune gastritis.Related Articles Multiplex autoantibody detection for autoimmune liver diseases and autoimmune gastritis. J Immunol Methods. 2017 May 15;: Authors: Vanderlocht J, van der Cruys M, Stals F, Bakker-Jonges L, Damoiseaux J Abstract Autoantibody detection for autoimmune hepatitis (AIH), primary biliary cirrhosis (PBC) and autoimmune gastritis (AIG) is traditionally performed by IIF on a combination of…
The Yield of Abdominal Ultrasound in the Evaluation of Elevated Liver Enzymes during the Second and the Third Trimester of Pregnancy.The Yield of Abdominal Ultrasound in the Evaluation of Elevated Liver Enzymes during the Second and the Third Trimester of Pregnancy. Gynecol Obstet Invest. 2017 May 19;: Authors: Mohr-Sasson A, Schiff E, Suday RR, Hayman Z, Kleinbaum Y, Kalter-Farber A, Mashiach R, Yinon Y, Dulitzki M, Sivan E, Mazaki-Tovi S Abstract AIMS: To determine the…
Clinical Course of Ulcerative Colitis After Liver Transplantation in Patients with Concomitant Primary Sclerosing Cholangitis and Ulcerative Colitis.Clinical Course of Ulcerative Colitis After Liver Transplantation in Patients with Concomitant Primary Sclerosing Cholangitis and Ulcerative Colitis. Inflamm Bowel Dis. 2017 May 16;: Authors: Fattahi MR, Malek-Hosseini SA, Sivandzadeh GR, Safarpour AR, Bagheri Lankarani K, Taghavi AR, Ejtehadi F Abstract BACKGROUND: The natural history of ulcerative colitis (UC) after liver transplantation (LT) for primary…
Treatment of Primary Biliary Cholangitis Non-responders: A Systematic Review.Treatment of Primary Biliary Cholangitis Non-responders: A Systematic Review. Liver Int. 2017 May 18;: Authors: Suraweera D, Rahal H, Jimenez M, Viramontes M, Choi G, Saab S Abstract BACKGROUND: Primary biliary cholangitis (PBC), formerly known as primary biliary cirrhosis, is a chronic cholestatic liver disease characterized by an immune mediated destruction of intrahepatic bile ducts.…
Topical mycophenolate mofetil in the treatment of vitiligo: a pilot study.Related Articles Topical mycophenolate mofetil in the treatment of vitiligo: a pilot study. Dermatol Pract Concept. 2017 Apr;7(2):31-33 Authors: Handjani F, Aghaei S, Moezzi I, Saki N Abstract BACKGROUND: Vitiligo is a multifactorial disease that is characterized by circumscribed depigmented macules and patches. Autoimmune reactions may play an important role in the pathogenesis of the…
Role of circulating microRNAs in liver diseases.Related Articles Role of circulating microRNAs in liver diseases. World J Hepatol. 2017 Apr 28;9(12):586-594 Authors: Loosen SH, Schueller F, Trautwein C, Roy S, Roderburg C Abstract MicroRNAs (miRNAs) are small RNAs regulate gene expression by inhibiting the turnover of their target mRNAs. In the last years, it became apparent that miRNAs are released into…
IgG4-related disease of the biliary tract and pancreas: clinical and experimental advances.IgG4-related disease of the biliary tract and pancreas: clinical and experimental advances. Curr Opin Gastroenterol. 2017 May 13;: Authors: Hubers LM, Beuers U Abstract PURPOSE OF REVIEW: IgG4-related disease (IgG4-RD) is an immune-mediated disease of unknown cause. It predominantly affects the biliary tract [IgG4-associated cholangitis (IAC)] and pancreas [autoimmune pancreatitis (AIP)] of mostly elderly men.…
Validity criteria for the diagnosis of fatty liver by M probe-based controlled attenuation parameter.Related Articles Validity criteria for the diagnosis of fatty liver by M probe-based controlled attenuation parameter. J Hepatol. 2017 May 12;: Authors: Wong VW, Petta S, Hiriart JB, Cammà C, Wong GL, Marra F, Vergniol J, Chan AW, Tuttolomondo A, Merrouche W, Chan HL, Le Bail B, Arena U, Craxì A, de Lédinghen V Abstract…
Autoimmune Hepatitis Overlap Syndromes and Liver Pathology.Related Articles Autoimmune Hepatitis Overlap Syndromes and Liver Pathology. Gastroenterol Clin North Am. 2017 Jun;46(2):345-364 Authors: Czaja AJ, Carpenter HA Abstract Autoimmune hepatitis (AIH) may have an atypical serum alkaline phosphatase elevation, antimitochondrial antibodies, histologic features of bile duct injury/loss, or cholangiographic findings of focal biliary strictures and dilations. These manifestations characterize the overlap syndromes.…
IgG4-related Disease and the Liver.Related Articles IgG4-related Disease and the Liver. Gastroenterol Clin North Am. 2017 Jun;46(2):195-216 Authors: Chen JH, Deshpande V Abstract Pathologists are likely to encounter IgG4-related disease in several organ systems. This article focuses on helping pathologists diagnose IgG4-related disease in the hepatobiliary system. Missing the diagnosis can result in unnecessary organ damage and/or unnecessary surgical…
Vedolizumab: a novel medical intervention in the treatment of primary sclerosing cholangitis.Related Articles Vedolizumab: a novel medical intervention in the treatment of primary sclerosing cholangitis. BMJ Case Rep. 2017 May 13;2017: Authors: Westerveld D, Grajo J, Beattie L, Glover S PMID: 28501828 [PubMed - in process]
Association of STAT4 and PTPN22 polymorphisms and their interactions with type-1 autoimmune hepatitis susceptibility in Chinese Han children.Association of STAT4 and PTPN22 polymorphisms and their interactions with type-1 autoimmune hepatitis susceptibility in Chinese Han children. Oncotarget. 2017 Apr 27;: Authors: Li X, Chen H, Cai Y, Zhang P, Chen Z Abstract AIMS: To investigate the impact of signal transducer and activator of transcription 4 (STAT4) and the protein tyrosine phosphatase N22 (PTPN22)…
Epidemiology and risk factors: intrahepatic cholangiocarcinoma.Related Articles Epidemiology and risk factors: intrahepatic cholangiocarcinoma. Hepatobiliary Surg Nutr. 2017 Apr;6(2):101-104 Authors: Gupta A, Dixon E Abstract Intrahepatic cholangiocarcinoma (ICC) is a rare entity with a distinct clinical course and epidemiology from hilar and extrahepatic cholangiocarcinoma. ICC makes up 8-10% of cholangiocarcinomas and 10-20% of all primary liver tumors. There remains a considerable…
Knockdown of Hepatic Gonadotropin-Releasing Hormone by Vivo-Morpholino Decreases Liver Fibrosis in Multidrug Resistance Gene 2 Knockout Mice by Down-Regulation of miR-200b.Related Articles Knockdown of Hepatic Gonadotropin-Releasing Hormone by Vivo-Morpholino Decreases Liver Fibrosis in Multidrug Resistance Gene 2 Knockout Mice by Down-Regulation of miR-200b. Am J Pathol. 2017 May 11;: Authors: Kyritsi K, Meng F, Zhou T, Wu N, Venter J, Francis H, Kennedy L, Onori P, Franchitto A, Bernuzzi F, Invernizzi P, McDaniel K, Mancinelli…
Disseminated cutaneous nocardiosis with ocular involvement.Related Articles Disseminated cutaneous nocardiosis with ocular involvement. J Eur Acad Dermatol Venereol. 2017 May 13;: Authors: Nishizawa A, Hirose M, Nagata Y, Takeuchi M, Satoh T Abstract A 45-year-old Japanese woman presented with a five-day history of multiple papular eruptions and a fever >38°C. For the past 10 years, she had been treated with…
The intestinal microbiome and paediatric liver disease.The intestinal microbiome and paediatric liver disease. Lancet Gastroenterol Hepatol. 2017 Jun;2(6):446-455 Authors: Leung DH, Yimlamai D Abstract The intestinal microbiome has been the intense focus of recent study, but how the microbiota affects connected organs, such as the liver, has not been fully elucidated. The microbiome regulates intestinal permeability and helps to metabolise the…
[Clinicopathologic features of drug-induced vanishing bile duct syndrome].Related Articles [Clinicopathologic features of drug-induced vanishing bile duct syndrome]. Zhonghua Gan Zang Bing Za Zhi. 2017 Apr 20;25(4):317-320 Authors: Ye LH, Wang CK, Zhang HC, Liu ZQ, Zheng HW Abstract Vanishing bile duct syndrome (VBDS) manifests as progressive destruction and disappearance of the intrahepatic bile duct caused by various factors and cholestasis. VBDS associated…
[Association between high expression of intrahepatic programmed death-1 and liver inflammation in patients with autoimmune hepatitis].Related Articles [Association between high expression of intrahepatic programmed death-1 and liver inflammation in patients with autoimmune hepatitis]. Zhonghua Gan Zang Bing Za Zhi. 2017 Apr 20;25(4):263-267 Authors: Xiong KG, Ke KY, Chen LF, Wei DH, Lin XQ, Chen L Abstract Objective: To investigate the expression of programmed death-1 (PD-1) in liver tissue and its…
Association of Autoimmune Hepatitis and Celiac Disease: Role of Gluten-Free Diet in Reversing Liver Dysfunction.Related Articles Association of Autoimmune Hepatitis and Celiac Disease: Role of Gluten-Free Diet in Reversing Liver Dysfunction. J Investig Med High Impact Case Rep. 2017 Apr-Jun;5(2):2324709617705679 Authors: Iqbal U, Chaudhary A, Karim MA, Siddiqui MA, Anwar H, Merrell N Abstract Autoimmune hepatitis (AIH) is a chronic inflammation of liver with unclear etiology. It is frequently…
[Clinical and laboratory characteristics of patients with pulmonary hypertension and pulmonary vascular complications hospitalized at the Instituto Nacional de Salud del Niño].Related Articles [Clinical and laboratory characteristics of patients with pulmonary hypertension and pulmonary vascular complications hospitalized at the Instituto Nacional de Salud del Niño]. Rev Gastroenterol Peru. 2017 Jan-Mar;37(1):9-15 Authors: Ormeño Julca AJ, Alvarez Murillo CM, Amoretti Alvino PM, Florian Florian AA, Castro Johanson RA, Celi Perez MD, Huamán Prado OR Abstract The hepatopulmonary syndrome…
Increased risk of portal vein thrombosis in patients with autoimmune hepatitis on the liver transplantation waiting list.Related Articles Increased risk of portal vein thrombosis in patients with autoimmune hepatitis on the liver transplantation waiting list. Clin Transplant. 2017 May 10;: Authors: Ruiz P, Sastre L, Crespo G, Blasi A, Colmenero J, García-Valdecasas JC, Navasa M Abstract Liver transplantation (LT) is indicated in autoimmune hepatitis (AIH) for both acute presentation with liver…
A predictive formula of coma onset and prothrombin time to distinguish patients who recover from acute liver injury.Related Articles A predictive formula of coma onset and prothrombin time to distinguish patients who recover from acute liver injury. J Gastroenterol Hepatol. 2017 May 09;: Authors: Kakisaka K, Suzuki Y, Kataoka K, Okada Y, Miyamoto Y, Kuroda H, Takikawa Y Abstract BACKGROUND & AIM: Acute liver failure (ALF) is defined as acute liver injury…
Incidence of Primary Biliary Cholangitis in a Rural Midwestern Population.Related Articles Incidence of Primary Biliary Cholangitis in a Rural Midwestern Population. Clin Med Res. 2017 May 09;: Authors: Kanth R, Shrestha RB, Rai I, VanWormer JJ, Roy PK Abstract BACKGROUND: Primary biliary cholangitis (PBC) is a rare disease with incidence that varies with time and geography. Only two studies have assessed PBC incidence of…
Diagnostic approach to Autoimmune Hepatitis.Related Articles Diagnostic approach to Autoimmune Hepatitis. Expert Rev Clin Immunol. 2017 May 08;: Authors: Muratori P, Lenzi M, Cassani F, Lalanne C, Muratori L Abstract INTRODUCTION: Autoimmune hepatitis (AIH) is a chronic inflammatory liver disease which, if left without treatment, can evolve into cirrhosis and possibly liver failure. The diagnosis of AIH is hampered…
Development of autoimmune hepatitis in a psoriasis patient without immunosuppressive therapy.Related Articles Development of autoimmune hepatitis in a psoriasis patient without immunosuppressive therapy. Clin Mol Hepatol. 2017 May 08;: Authors: Jo W, Suh YS, Lee SI, Cheon YH, Hong J, Lee SS, Kim JE, Ko GH, Kim HO Abstract We present a case of a 65-year-old man with psoriasis who developed autoimmune hepatitis (AIH) without…
Coffee and autoimmunity: More than a mere hot beverage!Related Articles Coffee and autoimmunity: More than a mere hot beverage! Autoimmun Rev. 2017 May 04;: Authors: Sharif K, Watad A, Bragazzi NL, Adawi M, Amital H, Shoenfeld Y Abstract Coffee is one of the world's most consumed beverage. In the last decades, coffee consumption has attracted a huge body of research due to its…
Immunosuppressive Agents for the Treatment of Primary Sclerosing Cholangitis: A Systematic Review and Meta-Analysis.Related Articles Immunosuppressive Agents for the Treatment of Primary Sclerosing Cholangitis: A Systematic Review and Meta-Analysis. Dig Dis. 2017 May 06;: Authors: Peng X, Luo X, Hou JY, Wu SY, Li LZ, Zheng MH, Wang LY Abstract OBJECTIVES: Currently, there are no effective therapeutic agents for patients with primary sclerosing cholangitis (PSC). This study aimed…
Hepatic venous pressure gradient correlates with advanced hepatic fibrosis: a retrospective review.Related Articles Hepatic venous pressure gradient correlates with advanced hepatic fibrosis: a retrospective review. Abdom Radiol (NY). 2017 May 04;: Authors: Vincent JK, Stark C, Shields JT, Bhave AD, Morris CS Abstract PURPOSE: To determine if hepatic venous pressure gradient (HVPG) correlates with advanced hepatic fibrosis, as a complement to transjugular (transvenous) core needle liver…
Glassy droplet inclusions within the cytoplasm of Kupffer cells: A novel ultrastructural feature for the diagnosis of pediatric autoimmune hepatitis.Related Articles Glassy droplet inclusions within the cytoplasm of Kupffer cells: A novel ultrastructural feature for the diagnosis of pediatric autoimmune hepatitis. Dig Liver Dis. 2017 Apr 12;: Authors: Lotowska JM, Sobaniec-Lotowska ME, Daniluk U, Lebensztejn DM Abstract Since Kupffer cells/macrophages (KCs/MPs) may be involved in the pathogenesis of autoimmune hepatitis (AIH), this pioneer study…
Autoreactive Monoclonal Antibodies from Patients with Primary Biliary Cholangitis Recognize Environmental Xenobiotics.Autoreactive Monoclonal Antibodies from Patients with Primary Biliary Cholangitis Recognize Environmental Xenobiotics. Hepatology. 2017 May 03;: Authors: Tanaka T, Zhang W, Sun Y, Shuai Z, Chida A, Kenny TP, Yang GX, Sanz I, Ansai A, Bowlus CL, Ippolito GC, Coppel RL, Okazaki K, He XS, Leung PSC, Gershwin ME Abstract A major problem in autoimmunity…
What Comes after Ursodeoxycholic Acid in Primary Biliary Cholangitis?What Comes after Ursodeoxycholic Acid in Primary Biliary Cholangitis? Dig Dis. 2017 May 03;35(4):359-366 Authors: Wong LL, Hegade VS, Jones DEJ Abstract Primary biliary cholangitis (PBC) is a rare autoimmune liver disease characterized by chronic cholestasis. Treatment with the accepted primary therapy ursodeoxycholic acid (UDCA) has been shown to be associated with delayed disease progression…
Can Understanding the Pathogenesis of Autoimmune Hepatitis Lead to Rational Therapy?Can Understanding the Pathogenesis of Autoimmune Hepatitis Lead to Rational Therapy? Dig Dis. 2017 May 03;35(4):367-370 Authors: Lohse AW, Herkel J, Weiler-Normann C Abstract The pathogenesis of autoimmune hepatitis is still poorly understood and therefore, the therapy administered to treat this condition is broadly targeted immunosuppression. However, the aim of therapy in the future should…
Successful Hepatoatrial Anastomosis During a Consecutive Liver Retransplant in the Same Patient Shows Good Long-Term Results: Case Report and 2-Year Follow-Up.Successful Hepatoatrial Anastomosis During a Consecutive Liver Retransplant in the Same Patient Shows Good Long-Term Results: Case Report and 2-Year Follow-Up. Exp Clin Transplant. 2017 May 03;: Authors: Kobryń K, Nyckowski P, Milkiewicz P, Niewiński G, Piwowarska J, Figiel W, Smoter P, Wasilewicz M, Patkowski W, Krawczyk M Abstract Liver retransplant is the last and…
Pathogenesis and clinical spectrum of primary sclerosing cholangitis.Related Articles Pathogenesis and clinical spectrum of primary sclerosing cholangitis. World J Gastroenterol. 2017 Apr 14;23(14):2459-2469 Authors: Gidwaney NG, Pawa S, Das KM Abstract Primary sclerosing cholangitis (PSC) is a disease of the biliary tract, which has been documented in the literature since 1867. This disease has a strong predilection for affecting men and can…
Predictors of the clinical course of primary sclerosing cholangitis.Related Articles Predictors of the clinical course of primary sclerosing cholangitis. Gastroenterology. 2017 Apr 28;: Authors: Kalaitzakis E, Björnsson ES PMID: 28461191 [PubMed - as supplied by publisher]
Reply to: Doublecortin domain containing protein 2 (DCDC2) genetic variants in primary sclerosing cholangitis.Related Articles Reply to: Doublecortin domain containing protein 2 (DCDC2) genetic variants in primary sclerosing cholangitis. J Hepatol. 2017 Apr 28;: Authors: Grammatikopoulos T, Thompson RJ PMID: 28461131 [PubMed - as supplied by publisher]
Doublecortin domain containing protein 2 (DCDC2) genetic variants in primary sclerosing cholangitis.Related Articles Doublecortin domain containing protein 2 (DCDC2) genetic variants in primary sclerosing cholangitis. J Hepatol. 2017 Apr 28;: Authors: Cheung AC, Juran BD, Moore RM, LaRusso NF, Lazaridis KN PMID: 28461130 [PubMed - as supplied by publisher]
The Gut Microbiota and the Hepatologist: Will Our Bugs Prove to be the Missing Link?The Gut Microbiota and the Hepatologist: Will Our Bugs Prove to be the Missing Link? Dig Dis. 2017 May 03;35(4):377-383 Authors: Pallen MJ, Quraishi MN Abstract The advent of next-generation sequencing has enabled in-depth analysis to study the composition and function of the gut microbiota in a culture-independent manner. Consequently, this has led to rapid…
Genetic Discoveries Highlight Environmental Factors as Key Drivers of Liver Disease.Genetic Discoveries Highlight Environmental Factors as Key Drivers of Liver Disease. Dig Dis. 2017 May 03;35(4):323-333 Authors: Chung BK, Karlsen TH Abstract BACKGROUND: Over the last 50 years, genetic studies have uncovered a spectrum of rare and common alleles that confer susceptibility to both Mendelian and complex forms of liver disease. For disorders of Mendelian…
Liver Retransplantation for Hepatic Abscess Due to Hepatic Artery Thrombosis: A Case Report.Related Articles Liver Retransplantation for Hepatic Abscess Due to Hepatic Artery Thrombosis: A Case Report. Transplant Proc. 2017 May;49(4):736-739 Authors: Zanus G, Romano M, Finotti M, Dalla Bona E, Sgarabotto D, Bassi D, Mescoli C, Angeli P, Burra P, Gringeri E, Vitale A, D'Amico F, Feltracco P, Cillo U Abstract INTRODUCTION: Hepatic artery thrombosis (HAT)…
Value of brush cytology for optimal timing of liver transplantation in primary sclerosing cholangitis.Related Articles Value of brush cytology for optimal timing of liver transplantation in primary sclerosing cholangitis. Liver Int. 2017 May;37(5):735-742 Authors: Vannas MJ, Boyd S, Färkkilä MA, Arola J, Isoniemi H Abstract BACKGROUND AND AIMS: Primary sclerosing cholangitis is associated with a high risk of cholangiocarcinoma. Here, we investigated the value of surveillance for dysplasia…
Expression and roles of TIPE2 in autoimmune hepatitis.Related Articles Expression and roles of TIPE2 in autoimmune hepatitis. Exp Ther Med. 2017 Mar;13(3):942-946 Authors: Qian J, Meng Z, Guan J, Zhang Z, Wang Y Abstract Tumor necrosis factor, alpha-induced protein 8-like 2 (TIPE2) is associated with the development of hepatic inflammatory diseases. However, to date, the possible role of TIPE2 in autoimmune hepatitis…
A case of chronic sarcoid myopathy with Basedow's disease and Sjogren's syndrome: A case series of sarcoid myopathy.Related Articles A case of chronic sarcoid myopathy with Basedow's disease and Sjogren's syndrome: A case series of sarcoid myopathy. Rinsho Shinkeigaku. 2017 Apr 27;: Authors: Isobe T, Mori-Yoshimura M, Oya Y, Saito Y, Murata M, Nishino I, Takahashi Y Abstract We report a 62-year-old woman with a history of Basedow's disease and Sjogren's syndrome…
Pregnancy and bile acid disorders.Related Articles Pregnancy and bile acid disorders. Am J Physiol Gastrointest Liver Physiol. 2017 Apr 27;:ajpgi.00028.2017 Authors: Pataia V, Dixon PH, Williamson C Abstract During pregnancy, extensive adaptations in maternal metabolic and immunological physiology occur. Consequently, pre-existing disease may be exacerbated or attenuated and new disease susceptibility may be unmasked. Cholestatic diseases, characterized by a…
rs10499194 polymorphism in the tumor necrosis factor-α inducible protein 3 (TNFAIP3) gene is associated with type-1 autoimmune hepatitis risk in Chinese Han population.rs10499194 polymorphism in the tumor necrosis factor-α inducible protein 3 (TNFAIP3) gene is associated with type-1 autoimmune hepatitis risk in Chinese Han population. PLoS One. 2017;12(4):e0176471 Authors: Xu E, Cao H, Lin L, Liu H Abstract Previous studies have found that the polymorphisms of tumor necrosis factor-α induced protein 3 (TNFAIP3) were associated with several…
Autoimmune polyendocrine syndrome type 1 in an Indian cohort: a longitudinal study.Related Articles Autoimmune polyendocrine syndrome type 1 in an Indian cohort: a longitudinal study. Endocr Connect. 2017 Apr 26;: Authors: Zaidi G, Bhatia V, Sahoo S, Sarangi AN, Bharti N, Zhang L, Yu L, Eriksson D, Bensing S, Kämpe O, Bhavani N, Yachha SK, Bhansali A, Sachan A, Jain V, Shah N, Aggarwal R, Aggarwal…
Chinese consensus on the diagnosis and management of autoimmune hepatitis (2015): Chinese Society of Hepatology, Chinese Society of Gastroenterology & Chinese Society of Infectious Diseases.Chinese consensus on the diagnosis and management of autoimmune hepatitis (2015): Chinese Society of Hepatology, Chinese Society of Gastroenterology & Chinese Society of Infectious Diseases. J Dig Dis. 2017 Apr 27;: Authors: Ma X, Qiu K Abstract Autoimmune hepatitis (AIH) is the inflammation of liver parenchyma mediated by the autoimmune response targeting hepatocytes, and is…
Lack of efficacy of infliximab in the treatment of primary sclerosing cholangitis in inflammatory bowel diseases in childhood.Lack of efficacy of infliximab in the treatment of primary sclerosing cholangitis in inflammatory bowel diseases in childhood. Eur J Gastroenterol Hepatol. 2017 Jun;29(6):736 Authors: Cardile S, Candusso M, Papadatou B, Bracci F, Knafelz D, Torre G PMID: 28441268 [PubMed - in process]
Methylprednisolone liver toxicity: A new case and a French regional pharmacovigilance survey.Related Articles Methylprednisolone liver toxicity: A new case and a French regional pharmacovigilance survey. Clin Res Hepatol Gastroenterol. 2017 Apr 21;: Authors: Dumortier J, Cottin J, Lavie C, Guillaud O, Hervieu V, Chambon-Augoyard C, Scoazec JY, Vukusic S, Vial T Abstract Reported hepatotoxicity induced by corticosteroids is very rare, and the diagnosis is highly challenging…
Autoimmune-like chronic hepatitis induced by olmesartan.Autoimmune-like chronic hepatitis induced by olmesartan. Hepatology. 2017 Apr 24;: Authors: Barge S, Ziol M, Nault JC Abstract Drug liver-induced injury (DILI) due to minocyclin, alpha methyldopa or nitrofurantoin may be responsible for chronic liver damage that mimic the biological and/or histological features of chronic autoimmune hepatitis and, in rare cases, progresses to cirrhosis(1). Olmesartan…
A 6-year-old boy with Wilson disease-A diagnostic dilemma.Related Articles A 6-year-old boy with Wilson disease-A diagnostic dilemma. Indian J Gastroenterol. 2017 Apr 24;: Authors: Ganesh R, Suresh N, Vasanthi T, Sathiyasekaran M, Thulasiraman R Abstract A 6-year-old boy presented with 2 months history of progressive abdominal distension and jaundice. He was deeply icteric with ascites, hepatosplenomegaly, hyperbilirubinemia, raised transaminases, and coagulopathy. Viral markers…
Anti-mitochondrial antibodies are not a hallmark of severity in idiopathic inflammatory myopathies.Related Articles Anti-mitochondrial antibodies are not a hallmark of severity in idiopathic inflammatory myopathies. Joint Bone Spine. 2017 Apr 20;: Authors: Mauhin W, Mariampillai K, Allenbach Y, Charuel JL, Musset L, Benveniste O PMID: 28435082 [PubMed - as supplied by publisher]
Wilson disease - liver pathology.Wilson disease - liver pathology. Handb Clin Neurol. 2017;142:71-75 Authors: Pronicki M Abstract The liver in Wilson disease may demonstrate a wide range of damage patterns. Some patients may present almost no detectable microscopic pathology, while others display lesions consistent with fulminant hepatitis or acute liver failure. Most liver biopsy specimens show moderate to severe…
Autoimmune hepatitis: from current knowledge and clinical practice to future research agenda.Autoimmune hepatitis: from current knowledge and clinical practice to future research agenda. Liver Int. 2017 Apr 22;: Authors: Sebode M, Hartl J, Vergani D, Lohse AW, International Autoimmune Hepatitis Group (IAIHG) Abstract Autoimmune hepatitis (AIH) is a chronic inflammatory liver disease. Unknown triggers lead to a mainly T cell-mediated immune response targeting the liver, the…
Association between progressive hepatic morphology changes on serial MR imaging and clinical outcome in primary sclerosing cholangitis.Related Articles Association between progressive hepatic morphology changes on serial MR imaging and clinical outcome in primary sclerosing cholangitis. J Med Imaging Radiat Oncol. 2017 Apr 22;: Authors: Kitzing YX, Whitley SA, Upponi SS, Srivastava B, Alexander GJ, Lomas DJ Abstract INTRODUCTION: Hepatic morphology changes are well described in Primary Sclerosing Cholangitis and characterised by…
Acute presentation of autoimmune hepatitis: a multicentre study with detailed histological evaluation in a large cohort of patients.Related Articles Acute presentation of autoimmune hepatitis: a multicentre study with detailed histological evaluation in a large cohort of patients. J Clin Pathol. 2017 Apr 20;: Authors: Nguyen Canh H, Harada K, Ouchi H, Sato Y, Tsuneyama K, Kage M, Nakano M, Yoshizawa K, Takahashi A, Abe M, Kang JH, Koike K, Inui A, Fujisawa…
EASL Clinical Practice Guidelines: The diagnosis and management of patients with primary biliary cholangitis.Related Articles EASL Clinical Practice Guidelines: The diagnosis and management of patients with primary biliary cholangitis. J Hepatol. 2017 Apr 17;: Authors: European Association for the Study of the Liver. Electronic address: easloffice@easloffice.eu, Hirschfield GM, Beuers U, Corpechot C, Invernizzi P, Jones D, Marzioni M, Schramm C Abstract Primary biliary cholangitis (PBC) is a chronic…
Role of endoscopy in primary sclerosing cholangitis: European Society of Gastrointestinal Endoscopy (ESGE) and European Association for the Study of the Liver (EASL) Clinical Guideline.Related Articles Role of endoscopy in primary sclerosing cholangitis: European Society of Gastrointestinal Endoscopy (ESGE) and European Association for the Study of the Liver (EASL) Clinical Guideline. J Hepatol. 2017 Apr 13;: Authors: European Society of Gastrointestinal Endoscopy, European Association for the Study of the Liver. Electronic address: easloffice@easloffice.eu, European Association for the Study of…
ApaI polymorphism of vitamin D receptor affects health-related quality of life in patients with primary sclerosing cholangitis.ApaI polymorphism of vitamin D receptor affects health-related quality of life in patients with primary sclerosing cholangitis. PLoS One. 2017;12(4):e0176264 Authors: Kempinska-Podhorodecka A, Milkiewicz M, Jabłonski D, Milkiewicz P, Wunsch E Abstract BACKGROUND: Polymorphisms of vitamin D receptor (VDR) contribute to the pathogenesis of multiple autoimmune conditions. METHODS: We investigated the incidence of VDR polymorphisms…
A genome-wide association study identifies six novel risk loci for primary biliary cholangitis.A genome-wide association study identifies six novel risk loci for primary biliary cholangitis. Nat Commun. 2017 Apr 20;8:14828 Authors: Qiu F, Tang R, Zuo X, Shi X, Wei Y, Zheng X, Dai Y, Gong Y, Wang L, Xu P, Zhu X, Wu J, Han C, Gao Y, Zhang K, Jiang Y, Zhou J, Shao Y,…
Ursodeoxycholic Acid Therapy in Patients with Primary Biliary Cholangitis with Limited Liver Transplantation Availability.Ursodeoxycholic Acid Therapy in Patients with Primary Biliary Cholangitis with Limited Liver Transplantation Availability. Ann Hepatol. 2017 May - Jun 2017;16(3):430-435 Authors: Melchor-Mendoza YK, Martínez-Benítez B, Mina-Hawat A, Rodríguez-Leal G, Duque X, Moran-Villota S Abstract INTRODUCTION: There is little information on survival rates of patients with primary biliary cholangtis (PBC) in developing countries. This is…
Role of endoscopy in primary sclerosing cholangitis: European Society of Gastrointestinal Endoscopy (ESGE) and European Association for the Study of the Liver (EASL) Clinical Guideline.Role of endoscopy in primary sclerosing cholangitis: European Society of Gastrointestinal Endoscopy (ESGE) and European Association for the Study of the Liver (EASL) Clinical Guideline. Endoscopy. 2017 Apr 18;: Authors: Aabakken L, Karlsen TH, Albert J, Arvanitakis M, Chazouilleres O, Dumonceau JM, Färkkilä M, Fickert P, Hirschfield GM, Laghi A, Marzioni M, Fernandez M, Pereira…
Pharmacological interventions for primary sclerosing cholangitis: an attempted network meta-analysis.Related Articles Pharmacological interventions for primary sclerosing cholangitis: an attempted network meta-analysis. Cochrane Database Syst Rev. 2017 Mar 28;3:CD011343 Authors: Saffioti F, Gurusamy KS, Hawkins N, Toon CD, Tsochatzis E, Davidson BR, Thorburn D Abstract BACKGROUND: Primary sclerosing cholangitis is a chronic cholestatic liver disease that is associated with both hepatobiliary and colorectal malignancies, which…
(31)Phosphorus magnetic resonance spectroscopy of the liver for evaluating inflammation and fibrosis in autoimmune hepatitis.Related Articles (31)Phosphorus magnetic resonance spectroscopy of the liver for evaluating inflammation and fibrosis in autoimmune hepatitis. Scand J Gastroenterol. 2017 Apr 17;:1-7 Authors: Puustinen L, Hakkarainen A, Kivisaari R, Boyd S, Nieminen U, Färkkilä M, Lundbom N, Arkkila P Abstract BACKGROUND: Liver biopsy is the gold standard in evaluating inflammation and fibrosis in autoimmune…
Interferon-α for Induction and Maintenance of Remission in Eosinophilic Granulomatosis with Polyangiitis: A Single-center Retrospective Observational Cohort Study.Interferon-α for Induction and Maintenance of Remission in Eosinophilic Granulomatosis with Polyangiitis: A Single-center Retrospective Observational Cohort Study. J Rheumatol. 2017 Apr 15;: Authors: Seeliger B, Förster M, Happe J, Forberg T, Moeser A, Neumann T, Kroegel C Abstract OBJECTIVE: Eosinophilic granulomatosis with polyangiitis (EGPA) is characterized by frequent relapses following induction therapy. Interferon-α (IFN-α)…
Preoperative Clostridium difficile Infection Does Not Affect Pouch Outcomes in Patients with Ulcerative Colitis Who Undergo Ileal Pouch-anal Anastomosis.Preoperative Clostridium difficile Infection Does Not Affect Pouch Outcomes in Patients with Ulcerative Colitis Who Undergo Ileal Pouch-anal Anastomosis. Inflamm Bowel Dis. 2017 Apr 13;: Authors: Lightner AL, Tse CS, Quinn K, Bergquist JR, Enders F, Pendegraft R, Khanna S, Raffals L Abstract BACKGROUND: The operation of choice for patients with chronic ulcerative colitis (CUC)…
H19 promotes cholestatic liver fibrosis by preventing ZEB1-mediated inhibition of EpCAM.H19 promotes cholestatic liver fibrosis by preventing ZEB1-mediated inhibition of EpCAM. Hepatology. 2017 Apr 13;: Authors: Song Y, Liu C, Liu X, Trottier J, Beaudoin M, Zhang L, Pope C, Peng G, Barbier O, Zhong X, Li L, Wang L Abstract Based on our recent finding that disruption of bile acid (BA) homeostasis in mice…
Translation and validation of the Serbian primary biliary cholangitis-40 questionnaire.Translation and validation of the Serbian primary biliary cholangitis-40 questionnaire. PLoS One. 2017;12(4):e0175697 Authors: Zec S, Popovic D, Matovic V, Nikolic V, Bojovic K, Jovic J, Markovic Denic L, Milosavljevic T, Alempijevic T Abstract BACKGROUND AND AIMS: To translate into Serbian and validate the Primary Biliary Cholangitis-40 (PBC-40) and PBC-27 questionnaires. MATERIALS AND METHODS: Ninety-four…
EVOLVING PARADIGM OF TREATMENT FOR AUTOIMMUNE HEPATITIS.EVOLVING PARADIGM OF TREATMENT FOR AUTOIMMUNE HEPATITIS. Expert Rev Clin Immunol. 2017 Apr 13;: Authors: Czaja AJ Abstract INTRODUCTION: Current medications for autoimmune hepatitis have broad anti-inflammatory and immunosuppressive actions, and their effects are short-lived and inconsistent. The goals of this review were to describe the actions and shortcomings of these medications, indicate the key…
Advances in primary sclerosing cholangitis.Related Articles Advances in primary sclerosing cholangitis. Lancet Gastroenterol Hepatol. 2016 Sep;1(1):68-77 Authors: Horsley-Silva JL, Carey EJ, Lindor KD Abstract Primary sclerosing cholangitis is a chronic, progressive cholangiopathy that frequently affects men and is associated with inflammatory bowel disease. Although the cause of the disease is still debated, a genetic association and link to immune-mediated…
A feasibility study of digital single-operator cholangioscopy for diagnostic and therapeutic procedure (with videos).Related Articles A feasibility study of digital single-operator cholangioscopy for diagnostic and therapeutic procedure (with videos). Medicine (Baltimore). 2017 Apr;96(15):e6619 Authors: Imanishi M, Ogura T, Kurisu Y, Onda S, Takagi W, Okuda A, Miyano A, Amano M, Nishioka N, Masuda D, Higuchi K Abstract Recently, the novel SpyGlass DS Direct Visualization system (SPY DS) has…
Detection of AMA-M2 in human saliva: Potentials in diagnosis and monitoring of primary biliary cholangitis.Related Articles Detection of AMA-M2 in human saliva: Potentials in diagnosis and monitoring of primary biliary cholangitis. Sci Rep. 2017 Apr 11;7(1):796 Authors: Lu C, Hou X, Li M, Wang L, Zeng P, Jia H, Chen J, Wei Y, He H, Liu X, Diao H Abstract Serum anti-mitochondrial antibody type 2 (AMA-M2) is considered as…
Serum Metabolomics Analysis Reveals a Distinct Metabolic Profile of Patients with Primary Biliary Cholangitis.Related Articles Serum Metabolomics Analysis Reveals a Distinct Metabolic Profile of Patients with Primary Biliary Cholangitis. Sci Rep. 2017 Apr 11;7(1):784 Authors: Hao J, Yang T, Zhou Y, Gao GY, Xing F, Peng Y, Tao YY, Liu CH Abstract Primary biliary cholangitis (PBC) is a chronic autoimmune liver disease associated with profound metabolic changes. The…
Stratified medicine and primary biliary cholangitis.Stratified medicine and primary biliary cholangitis. Lancet Gastroenterol Hepatol. 2017 May;2(5):319-321 Authors: Mells GF, Jones DE PMID: 28397694 [PubMed - in process]
Patients with primary sclerosing cholangitis require more sedation during endoscopic retrograde cholangiography.Related Articles Patients with primary sclerosing cholangitis require more sedation during endoscopic retrograde cholangiography. Endosc Int Open. 2017 Apr;5(4):E315-E320 Authors: Keil C, Aguirre Dávila L, Framke T, Lenzen H, Manns MP, Lankisch TO, Voigtländer T Abstract Background and study aims Patients with primary sclerosing cholangitis (PSC) require repeated endoscopic retrograde cholangiography (ERC). Our aim was to…
Should anti-LKM1 be routine for work-up of elevated liver enzymes?Related Articles Should anti-LKM1 be routine for work-up of elevated liver enzymes? J Hepatol. 2017 Apr 06;: Authors: Agrawal D, Davis B, Quinn A, Thiele D PMID: 28392232 [PubMed - as supplied by publisher]
Differences in Phenotypes and Liver Transplantation Outcomes by Age Group in Patients with Primary Sclerosing Cholangitis.Related Articles Differences in Phenotypes and Liver Transplantation Outcomes by Age Group in Patients with Primary Sclerosing Cholangitis. Dig Dis Sci. 2017 Apr 08;: Authors: Henson JB, Patel YA, Wilder JM, Zheng J, Chow SC, King LY, Muir AJ Abstract BACKGROUND: There is increasing evidence for a heterogeneity of phenotypes in primary sclerosing cholangitis (PSC),…
The natural history of primary sclerosing cholangitis in 781 children: A multicenter, international collaboration.The natural history of primary sclerosing cholangitis in 781 children: A multicenter, international collaboration. Hepatology. 2017 Apr 08;: Authors: Deneau MR, El-Matary W, Valentino PL, Abdou R, Alqoaer K, Amin M, Amir AZ, Auth M, Bazerbachi F, Broderick A, Chan A, Cotter J, Doan S, El-Youssef M, Ferrari F, Furuya KN, Gottrand M, Gottrand F,…
Antimitochondrial antibodies positive autoimmune hepatitis with acute onset.Related Articles Antimitochondrial antibodies positive autoimmune hepatitis with acute onset. Scand J Gastroenterol. 2017 Apr 07;:1-2 Authors: Muratori P, Lenzi M, Migliori M, Muratori L PMID: 28388847 [PubMed - as supplied by publisher]
Surgery of a nocardia lung abscess presenting as a tension pyopneumothorax.Surgery of a nocardia lung abscess presenting as a tension pyopneumothorax. Asian Cardiovasc Thorac Ann. 2017 Jan 01;:218492317705286 Authors: Fujimoto R, Omasa M, Ishikawa H, Aoki M Abstract While some cases of nocardial pneumonia develop secondary empyema, tension pyopneumothorax is a very rare and lethal complication. A 74-year-old man who exhibited thrombocytopenia during steroid therapy…
Management Of Primary Sclerosing Cholangitis.Related Articles Management Of Primary Sclerosing Cholangitis. Gastroenterol Hepatol (N Y). 2006 Nov;2(11):843-849 Authors: Sandhu BS, Luketic VA Abstract Management of primary sclerosing cholangitis (PSC) can be divided into endoscopic, medical, and surgical treatments. Whereas endoscopic therapy is primarily used to manage dominant strictures, medical treatment is directed both at modifying course of the disease…
The Treatment of Hepatic Fibrosis: Reversal of the Underlying Disease Process.Related Articles The Treatment of Hepatic Fibrosis: Reversal of the Underlying Disease Process. Gastroenterol Hepatol (N Y). 2006 Nov;2(11):819-825 Authors: Servin-Abad L, Schiff ER Abstract Cirrhosis is considered an irreversible end stage of all liver diseases. Current knowledge indicates that fibrosis is part of the liver repair process, which is dynamic. Understanding this repair process…
Treatment of Severe Hypercholesterolemia in a Woman With Advanced Primary Sclerosing Cholangitis.Treatment of Severe Hypercholesterolemia in a Woman With Advanced Primary Sclerosing Cholangitis. JAMA Cardiol. 2017 Apr 05;: Authors: Xiao C, Hegele RA, Lewis GF PMID: 28384790 [PubMed - as supplied by publisher]
Th1 and Innate Lymphoid Cells accumulate in Primary Sclerosing Cholangitis-associated Inflammatory Bowel Disease.Th1 and Innate Lymphoid Cells accumulate in Primary Sclerosing Cholangitis-associated Inflammatory Bowel Disease. J Crohns Colitis. 2017 Apr 05;: Authors: Gwela A, Siddhanathi P, Oxford IBD Cohort Investigators, Chapman RW, Travis S, Powrie F, Arancibia-Cárcamo CV, Geremia A Abstract Background and Aims: Primary sclerosing cholangitis (PSC) is an idiopathic chronic disorder of the hepatobiliary system…
Spectrum of immune-related conditions associated with risk of keratinocyte cancers among elderly adults in the United States.Related Articles Spectrum of immune-related conditions associated with risk of keratinocyte cancers among elderly adults in the United States. Cancer Epidemiol Biomarkers Prev. 2017 Apr 04;: Authors: Yanik EL, Pfeiffer RM, Freedman DM, Weinstock MA, Cahoon EK, Arron ST, Chaloux M, Connolly MK, Nagarajan P, Engels EA Abstract Elevated keratinocyte carcinoma (KC) risk is present…
The clinical extremes of autoimmune cholangitis.Related Articles The clinical extremes of autoimmune cholangitis. Rev Esp Enferm Dig. 2017 Apr 03;109: Authors: Campos S, Gomes D, Cipriano MA, Sofia C Abstract Autoimmune cholangitis (AIC) was first described in 1987 as immunocholangitis in three women who presented with signs and symptoms of primary biliary cholangitis (PBC), but who were antimitochondrial (AMA) negative…
Inflammatory Bowel Disease and Primary Sclerosing Cholangitis: A Review of the Phenotype and Associated Specific Features.Inflammatory Bowel Disease and Primary Sclerosing Cholangitis: A Review of the Phenotype and Associated Specific Features. Gut Liver. 2017 Apr 06;: Authors: Palmela C, Peerani F, Castaneda D, Torres J, Itzkowitz SH Abstract Primary sclerosing cholangitis (PSC) is a chronic, progressive cholestatic disease that is associated with inflammatory bowel disease (IBD) in approximately 70% of…
[Hepatic manifestation of a macrophage activation syndrome (MAS)].[Hepatic manifestation of a macrophage activation syndrome (MAS)]. Z Gastroenterol. 2017 Apr 04;: Authors: Nagel M, Schwarting A, Straub BK, Galle PR, Zimmermann T Abstract Background Elevated liver values are the most common pathological laboratory result in Germany. Frequent findings, especially in younger patients, are nutritive- or medicamentous- toxic reasons, viral or autoimmune hepatitis. A macrophage…
Enrichment of Genetic Variants in the Glucocorticoid Receptor Signalling Pathway in Autoimmune Hepatitis with Failure of Standard Treatment.Enrichment of Genetic Variants in the Glucocorticoid Receptor Signalling Pathway in Autoimmune Hepatitis with Failure of Standard Treatment. Basic Clin Pharmacol Toxicol. 2017 Apr 04;: Authors: Eriksen PL, Kreutzfeldt M, Grønbaek H, Thorsen K, Vang S, Jessen N, Vilstrup H Abstract The standard treatment for autoimmune hepatitis (AIH) is predniso(lo)ne for remission induction, tapered and…
Severe infection with multidrug-resistant Salmonella choleraesuis in a young patient with primary sclerosing cholangitis.Related Articles Severe infection with multidrug-resistant Salmonella choleraesuis in a young patient with primary sclerosing cholangitis. World J Gastroenterol. 2017 Mar 21;23(11):2086-2089 Authors: Ferstl PG, Reinheimer C, Jozsa K, Zeuzem S, Kempf VA, Waidmann O, Grammatikos G Abstract Massive global spread of multidrug-resistant (MDR) Salmonella spp. expressing extended-spectrum beta-lactamase (ESBL) and additional resistance to fluoroquinolones…
Primary Biliary Cholangitis: Its Pathological Characteristics and Immunopathological Mechanisms.Related Articles Primary Biliary Cholangitis: Its Pathological Characteristics and Immunopathological Mechanisms. J Med Invest. 2017;64(1.2):7-13 Authors: Tsuneyama K, Baba H, Morimoto Y, Tsunematsu T, Ogawa H Abstract Primary biliary cholangitis (PBC), formerly known as primary biliary cirrhosis, is an organ-specific autoimmune disease that predominantly affects middle-aged women and is characterized by the chronic progressive destruction…
Exposure cessation during adulthood did not prevent immunotoxicity caused by developmental exposure to low-level trichloroethylene in drinking water.Exposure cessation during adulthood did not prevent immunotoxicity caused by developmental exposure to low-level trichloroethylene in drinking water. Toxicol Sci. 2017 Mar 24;: Authors: Gilbert KM, Bai S, Barnette D, Blossom SJ Abstract Exposure to the water pollutant trichloroethylene (TCE) can promote autoimmunity in both humans and rodents. Using a mouse model we have shown…
Geoepidemiology and changing mortality in primary biliary cholangitis.Related Articles Geoepidemiology and changing mortality in primary biliary cholangitis. J Gastroenterol. 2017 Apr 01;: Authors: Floreani A, Tanaka A, Bowlus C, Gershwin ME Abstract Primary biliary cholangitis (PBC), formerly called primary biliary cirrhosis, is a chronic cholestatic disease characterized by an autoimmune-mediated destruction of small and medium-sized intrahepatic bile ducts. Originally PBC was considered…
[Thymoma and autoimmune diseases].Related Articles [Thymoma and autoimmune diseases]. Rev Med Interne. 2017 Mar 29;: Authors: Jamilloux Y, Frih H, Bernard C, Broussolle C, Petiot P, Girard N, Sève P Abstract The association between thymoma and autoimmunity is well known. Besides myasthenia gravis, which is found in 15 to 20% of patients with thymoma, other autoimmune diseases have…
Cholestatic Liver Diseases After Liver Transplant.Related Articles Cholestatic Liver Diseases After Liver Transplant. Clin Liver Dis. 2017 May;21(2):403-420 Authors: Pena Polanco NA, Levy C, Martin EF Abstract Primary sclerosing cholangitis (PSC) and primary biliary cholangitis (PBC) are the most common cholestatic liver diseases (CLD) in adults. Liver transplant (LT) is desirable for those who progress to end-stage liver disease. CLD…
Autoimmune Hepatitis in the Liver Transplant Graft.Related Articles Autoimmune Hepatitis in the Liver Transplant Graft. Clin Liver Dis. 2017 May;21(2):381-401 Authors: Beal EW, Black SM, Michaels A Abstract Recurrent autoimmune hepatitis (AIH) and de novo AIH are 2 important causes of late graft failure after liver transplantation (LT). Recurrent AIH occurs in patients who undergo LT for AIH. De novo AIH…
Vitamin A deficiency in chronic cholestatic liver disease -is vitamin A therapy beneficial ?Vitamin A deficiency in chronic cholestatic liver disease -is vitamin A therapy beneficial ? Liver Int. 2017 Mar 29;: Authors: Freund C, Gotthardt DN Abstract Chronic cholestatic diseases are progressive diseases of the biliary tract that cause hepatic fibrosis and ultimately lead to liver failure. Liver transplantation is the sole curative option currently available, and…
Old and new treatments for primary biliary cholangitis.Old and new treatments for primary biliary cholangitis. Liver Int. 2017 Apr;37(4):490-499 Authors: Chascsa D, Carey EJ, Lindor KD Abstract Primary biliary cholangitis (formerly primary biliary cirrhosis) is a rare progressive cholestatic liver disease, whose hallmark features include a persistently elevated alkaline phosphatase level, presence of anti-mitochondrial antibodies and characteristic histology. Since 1998, ursodeoxycholic acid…
Treatment of PBC-A step forward.Treatment of PBC-A step forward. Liver Int. 2017 Apr;37(4):503-505 Authors: Carbone M, Invernizzi P Abstract Recent years have seen a growing interest in PBC within the scientific community, healthcare providers and industries, coupled with great advances in the understanding of the molecular and genetic basis and the natural history of the disease. Several disease-modifying agents…
Finding the cure for primary biliary cholangitis - Still waiting.Finding the cure for primary biliary cholangitis - Still waiting. Liver Int. 2017 Apr;37(4):500-502 Authors: Tanaka A, Gershwin ME Abstract The introduction of ursodeoxycholic acid (UDCA)may well have contributed to some of the improvements in morbidity and mortality of primary biliary cholangitis (PBC). Yet nearly 40% of PBC patients are unresponsive to UDCA. Further the…
Factors associated with long-term survival after liver transplantation: A retrospective cohort study.Related Articles Factors associated with long-term survival after liver transplantation: A retrospective cohort study. World J Hepatol. 2017 Mar 18;9(8):427-435 Authors: Pischke S, Lege MC, von Wulffen M, Galante A, Otto B, Wehmeyer MH, Herden U, Fischer L, Nashan B, Lohse AW, Sterneck M Abstract AIM: To identify predictive factors associated with long-term patient and…
Viral hepatitis and Parkinson disease: A national record-linkage study.Related Articles Viral hepatitis and Parkinson disease: A national record-linkage study. Neurology. 2017 Mar 29;: Authors: Pakpoor J, Noyce A, Goldacre R, Selkihova M, Mullin S, Schrag A, Lees A, Goldacre M Abstract OBJECTIVE: To study associations between viral hepatitis and Parkinson disease (PD). METHODS: A retrospective cohort study was done by analyzing linked English…
Pharmacological interventions for primary biliary cholangitis: an attempted network meta-analysis.Related Articles Pharmacological interventions for primary biliary cholangitis: an attempted network meta-analysis. Cochrane Database Syst Rev. 2017 Mar 28;3:CD011648 Authors: Saffioti F, Gurusamy KS, Eusebi LH, Tsochatzis E, Davidson BR, Thorburn D Abstract BACKGROUND: Primary biliary cholangitis (previously primary biliary cirrhosis) is a chronic liver disease caused by the destruction of small intra-hepatic bile ducts…
Neonatal cholestasis due to primary sclerosing cholangitis.Related Articles Neonatal cholestasis due to primary sclerosing cholangitis. J Family Med Prim Care. 2016 Oct-Dec;5(4):863-864 Authors: Shetty NS, Shah I Abstract Neonatal cholestasis is rarely caused due to primary sclerosing cholangitis, which is an inflammatory disease of the bile ducts, which results in obstructive fibrosis of the ducts. A 7-month-old male child presented with…
Role of Allopurinol in Optimizing Thiopurine Therapy in Patients with Autoimmune Hepatitis: A Review.Related Articles Role of Allopurinol in Optimizing Thiopurine Therapy in Patients with Autoimmune Hepatitis: A Review. J Clin Exp Hepatol. 2017 Mar;7(1):55-62 Authors: Deswal S, Srivastava A Abstract Autoimmune hepatitis (AIH) is a chronic immune mediated liver disease characterized by elevated transaminases, hyper gammaglobulinemia, presence of autoantibodies and interface hepatitis in the absence of a…
Impact of Hepatic and Extrahepatic Insults on the Outcome of Acute-on-Chronic Liver Failure.Related Articles Impact of Hepatic and Extrahepatic Insults on the Outcome of Acute-on-Chronic Liver Failure. J Clin Exp Hepatol. 2017 Mar;7(1):9-15 Authors: Gupta T, Dhiman RK, Rathi S, Agrawal S, Duseja A, Taneja S, Chawla Y Abstract BACKGROUND: To study the differences in outcome and predictors of mortality in acute-on-chronic liver failure (ACLF) precipitated by…
Rhupus and autoimmune hepatitis: A rare association.Related Articles Rhupus and autoimmune hepatitis: A rare association. Reumatol Clin. 2017 Mar 24;: Authors: Zavala-Flores E, Loja-Oropeza D PMID: 28347609 [PubMed - as supplied by publisher]
Re: The role of Th1/Th2 cells and associated cytokines in autoimmune hepatitis.Re: The role of Th1/Th2 cells and associated cytokines in autoimmune hepatitis. Turk J Gastroenterol. 2017 Mar;28(2):115-116 Authors: Akkoç T PMID: 28346187 [PubMed - in process]
Risk of rectal neoplasia after colectomy and ileorectal anastomosis for ulcerative colitis.Risk of rectal neoplasia after colectomy and ileorectal anastomosis for ulcerative colitis. J Crohns Colitis. 2017 Feb 21;: Authors: Uzzan M, Kirchgesner J, Oubaya N, Amiot A, Gornet JM, Seksik P, Nancey S, Cotte E, Allez M, Boschetti G, Laharie D, de Angelis N, Nachury M, Pelletier AL, Abitbol V, Fumery M, Brouquet A, Buisson…
Protection against oxidative stress mediated by the Nrf2/Keap1 axis is impaired in Primary Biliary Cholangitis.Protection against oxidative stress mediated by the Nrf2/Keap1 axis is impaired in Primary Biliary Cholangitis. Sci Rep. 2017 Mar 23;7:44769 Authors: Wasik U, Milkiewicz M, Kempinska-Podhorodecka A, Milkiewicz P Abstract In response to oxidative stress, nuclear factor (erythroid-derived 2)-like2 (Nrf2) induces expression of cytoprotective genes. The Nrf2 pathway is controlled by microRNAs and Kelch-like ECH-associated…